Bibliographic Details
| Title: |
Correlation between (18)F-FDG uptake on PET/CT and prognostic factors in triple-negative breast cancer. |
| Authors: |
Koo, Hye, Park, Jeong1, Kang, Keon2, Han, Wonshik3, Park, In4, Moon, Woo5 moonwk@snu.ac.kr, Koo, Hye Ryoung6,7 (AUTHOR), Park, Jeong Seon7 (AUTHOR), Kang, Keon Wook8 (AUTHOR), Park, In Ae9 (AUTHOR), Moon, Woo Kyung6 (AUTHOR) |
| Source: |
European Radiology. Nov2015, Vol. 25 Issue 11, p3314-3321. 8p. 1 Color Photograph, 2 Charts, 2 Graphs. |
| Subjects: |
Fluorodeoxyglucose F18, Breast cancer prognosis, Breast cancer patients, Positron emission tomography, Computed tomography, Statistical correlation, Breast cancer diagnosis, Breast tumor diagnosis, Ductal carcinoma, Anthropometry, Deoxy sugars, Prognosis, Radiopharmaceuticals, Tumor markers, Diagnosis |
| Abstract: |
Objectives: The purpose of this study was to investigate whether a correlation exists between (18)F-fluorodeoxyglucose (FDG) uptake and prognostic factors in triple-negative breast cancer (TNBC).Methods: Between January 2009 and December 2013, 103 patients (mean age, 50.6 years) with primary TNBC (mean, 2.6 cm; range, 1.0-6.5 cm) underwent (18)F-FDG PET/CT for initial staging. Correlations between maximum standardized uptake value (SUVmax) on PET/CT and prognostic factors including tumour size, nodal status, histological grade, Ki-67 proliferation index, tumour suppressor p53, and 'basal-like' markers (epidermal growth factor receptor and CK 5/6) were assessed.Results: The mean SUVmax of the 103 tumours was 10.94 ± 5.25 (range: 2-32.8). There was a positive correlation between SUVmax and Ki-67 (Spearman's rho = 0.29, P = 0.003) and tumour size (Spearman's rho = 0.27, P = 0.006), whereas this relationship was not observed in the nodal status, histological grade, p53 status and 'basal-like' phenotypes. In a multivariate regression analysis, Ki-67 (P < 0.001) and tumour size (P = 0.009) were significantly associated with SUVmax in TNBCs.Conclusions: Increased (18)F-FDG uptake on PET/CT was correlated with a high Ki-67 proliferation index and larger tumour size in TNBC. These results suggest a potential role of (18)F-FDG PET/CT in identifying TNBC with more aggressive behaviour.Key Points: • A wide range of FDG uptake reflected heterogeneity of cancer metabolism. • FDG uptake was correlated with the Ki-67 proliferation index in TNBC. • FDG uptake was correlated with tumour size in TNBC. • FDG uptake was not correlated with 'basal-like' phenotype. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Engineering Source |
