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In-situ synthesis of polyacrylate grafted carboxymethyl guargum–carbon nanotube membranes for potential application in controlled drug delivery.

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Title: In-situ synthesis of polyacrylate grafted carboxymethyl guargum–carbon nanotube membranes for potential application in controlled drug delivery.
Authors: Giri, Arindam1, Bhunia, Tridib2, Pal, Abhijit1, Goswami, Luna3, Bandyopadhyay, Abhijit1 abpoly@caluniv.ac.in
Source: European Polymer Journal. Jan2016, Vol. 74, p13-25. 13p.
Subjects: Polyacrylates, Chemical synthesis, Surface grafting (Polymer chemistry), Carboxymethyl compounds, Controlled release drugs, Carbon nanotubes, Medical polymers
Abstract: Sustainable hydrophobic membranes were prepared in-situ from the composites of poly (diethylene glycol dimethacrylate) grafted carboxymethyl guargum (CMG-g-PDEGDMA)/carboxy functionalized multiwalled carbon nanotube (f-MWCNT). The composite membranes were applied for transdermal delivery of hydrophobic diclofenac sodium. The uniform dispersion of f-MWCNT resulted into stronger–matrix filler interaction, particularly at 1 wt.% f-MWCNT concentration. The membrane was most hydrophobic and least drug eluting. At higher f-MWCNT loading i.e. at 2 and 3 wt.% the membranes were less hydrophobic and faster drug eluting as a consequence of relatively poor matrix–filler interaction and copolymer wrapping. The most hydrophobic formulation (1 wt.%) had released 16.4% of the encapsulated drug, while the least (3 wt.%) had released 42% after 20 h study in a Franz diffusion cell under physiological condition. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Sustainable hydrophobic membranes were prepared in-situ from the composites of poly (diethylene glycol dimethacrylate) grafted carboxymethyl guargum (CMG-g-PDEGDMA)/carboxy functionalized multiwalled carbon nanotube (f-MWCNT). The composite membranes were applied for transdermal delivery of hydrophobic diclofenac sodium. The uniform dispersion of f-MWCNT resulted into stronger–matrix filler interaction, particularly at 1 wt.% f-MWCNT concentration. The membrane was most hydrophobic and least drug eluting. At higher f-MWCNT loading i.e. at 2 and 3 wt.% the membranes were less hydrophobic and faster drug eluting as a consequence of relatively poor matrix–filler interaction and copolymer wrapping. The most hydrophobic formulation (1 wt.%) had released 16.4% of the encapsulated drug, while the least (3 wt.%) had released 42% after 20 h study in a Franz diffusion cell under physiological condition. [ABSTRACT FROM AUTHOR]
ISSN:00143057
DOI:10.1016/j.eurpolymj.2015.11.007