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In-situ synthesis of polyacrylate grafted carboxymethyl guargum–carbon nanotube membranes for potential application in controlled drug delivery.

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Title: In-situ synthesis of polyacrylate grafted carboxymethyl guargum–carbon nanotube membranes for potential application in controlled drug delivery.
Authors: Giri, Arindam1, Bhunia, Tridib2, Pal, Abhijit1, Goswami, Luna3, Bandyopadhyay, Abhijit1 abpoly@caluniv.ac.in
Source: European Polymer Journal. Jan2016, Vol. 74, p13-25. 13p.
Subjects: Polyacrylates, Chemical synthesis, Surface grafting (Polymer chemistry), Carboxymethyl compounds, Controlled release drugs, Carbon nanotubes, Medical polymers
Abstract: Sustainable hydrophobic membranes were prepared in-situ from the composites of poly (diethylene glycol dimethacrylate) grafted carboxymethyl guargum (CMG-g-PDEGDMA)/carboxy functionalized multiwalled carbon nanotube (f-MWCNT). The composite membranes were applied for transdermal delivery of hydrophobic diclofenac sodium. The uniform dispersion of f-MWCNT resulted into stronger–matrix filler interaction, particularly at 1 wt.% f-MWCNT concentration. The membrane was most hydrophobic and least drug eluting. At higher f-MWCNT loading i.e. at 2 and 3 wt.% the membranes were less hydrophobic and faster drug eluting as a consequence of relatively poor matrix–filler interaction and copolymer wrapping. The most hydrophobic formulation (1 wt.%) had released 16.4% of the encapsulated drug, while the least (3 wt.%) had released 42% after 20 h study in a Franz diffusion cell under physiological condition. [ABSTRACT FROM AUTHOR]
Copyright of European Polymer Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 111568668
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: In-situ synthesis of polyacrylate grafted carboxymethyl guargum–carbon nanotube membranes for potential application in controlled drug delivery.
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  Data: <searchLink fieldCode="JN" term="%22European+Polymer+Journal%22">European Polymer Journal</searchLink>. Jan2016, Vol. 74, p13-25. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Polyacrylates%22">Polyacrylates</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+synthesis%22">Chemical synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+grafting+%28Polymer+chemistry%29%22">Surface grafting (Polymer chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Carboxymethyl+compounds%22">Carboxymethyl compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Carbon+nanotubes%22">Carbon nanotubes</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+polymers%22">Medical polymers</searchLink>
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  Data: Sustainable hydrophobic membranes were prepared in-situ from the composites of poly (diethylene glycol dimethacrylate) grafted carboxymethyl guargum (CMG-g-PDEGDMA)/carboxy functionalized multiwalled carbon nanotube (f-MWCNT). The composite membranes were applied for transdermal delivery of hydrophobic diclofenac sodium. The uniform dispersion of f-MWCNT resulted into stronger–matrix filler interaction, particularly at 1 wt.% f-MWCNT concentration. The membrane was most hydrophobic and least drug eluting. At higher f-MWCNT loading i.e. at 2 and 3 wt.% the membranes were less hydrophobic and faster drug eluting as a consequence of relatively poor matrix–filler interaction and copolymer wrapping. The most hydrophobic formulation (1 wt.%) had released 16.4% of the encapsulated drug, while the least (3 wt.%) had released 42% after 20 h study in a Franz diffusion cell under physiological condition. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Polymer Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.eurpolymj.2015.11.007
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      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 13
    Subjects:
      – SubjectFull: Polyacrylates
        Type: general
      – SubjectFull: Chemical synthesis
        Type: general
      – SubjectFull: Surface grafting (Polymer chemistry)
        Type: general
      – SubjectFull: Carboxymethyl compounds
        Type: general
      – SubjectFull: Controlled release drugs
        Type: general
      – SubjectFull: Carbon nanotubes
        Type: general
      – SubjectFull: Medical polymers
        Type: general
    Titles:
      – TitleFull: In-situ synthesis of polyacrylate grafted carboxymethyl guargum–carbon nanotube membranes for potential application in controlled drug delivery.
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          Name:
            NameFull: Giri, Arindam
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            NameFull: Bhunia, Tridib
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            NameFull: Pal, Abhijit
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            NameFull: Goswami, Luna
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            NameFull: Bandyopadhyay, Abhijit
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            – D: 01
              M: 01
              Text: Jan2016
              Type: published
              Y: 2016
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              Value: 74
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            – TitleFull: European Polymer Journal
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