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A Shear horizontal surface acoustic wave biosensor for a rapid and specific detection of d-serine.

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Title: A Shear horizontal surface acoustic wave biosensor for a rapid and specific detection of d-serine.
Authors: Di Pietrantonio, F.1, Benetti, M.1, Cannatà, D.1, Verona, E.2, Girasole, M.3, Fosca, M.3, Dinarelli, S.3, Staiano, M.4, Marzullo, V.M.5, Capo, A.4, Varriale, A.4, D’Auria, S.4 sabato.dauria@cnr.it
Source: Sensors & Actuators B: Chemical. Apr2016, Vol. 226, p1-6. 6p.
Subjects: Shear (Mechanics), Surface acoustic wave sensors, Serine, Amino acids, Cellular signal transduction, Aspartates
Abstract: d -serine is an amino acid that has an important role in the regulation of N-methyl- d -aspartate (NMDA) signalling in the central nervous system. In fact, it acts as an endogenous co-agonist molecule for the NMDA receptor activation. Since an abnormal body level of d -amino acids is usually associated to different neurological diseases, it appears evident that it is of high interest to develop a fast and specific biosensor for the determination of d -serine. In this work, we report on the design and development of a surface acoustic wave (SAW) biosensor to detect the level of d -serine. The SAW-biosensor is based on the utilization of an inactivated form of the d -serine dehydratase isolated from Saccharomyces cerevisiae , a biomolecule that is able to specifically bind d -serine. In particular, we produced a PLP-reduced d -serine dehydratase biomolecule that was still able to bind d -serine and not to transform it into the product. The binding event between the “inactivated” d -serine dehydratase and d -serine was monitored by SAW delay-lines. [ABSTRACT FROM AUTHOR]
Copyright of Sensors & Actuators B: Chemical is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 112550921
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A Shear horizontal surface acoustic wave biosensor for a rapid and specific detection of d-serine.
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  Data: <searchLink fieldCode="JN" term="%22Sensors+%26+Actuators+B%3A+Chemical%22">Sensors & Actuators B: Chemical</searchLink>. Apr2016, Vol. 226, p1-6. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Shear+%28Mechanics%29%22">Shear (Mechanics)</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+acoustic+wave+sensors%22">Surface acoustic wave sensors</searchLink><br /><searchLink fieldCode="DE" term="%22Serine%22">Serine</searchLink><br /><searchLink fieldCode="DE" term="%22Amino+acids%22">Amino acids</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+signal+transduction%22">Cellular signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22Aspartates%22">Aspartates</searchLink>
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  Data: d -serine is an amino acid that has an important role in the regulation of N-methyl- d -aspartate (NMDA) signalling in the central nervous system. In fact, it acts as an endogenous co-agonist molecule for the NMDA receptor activation. Since an abnormal body level of d -amino acids is usually associated to different neurological diseases, it appears evident that it is of high interest to develop a fast and specific biosensor for the determination of d -serine. In this work, we report on the design and development of a surface acoustic wave (SAW) biosensor to detect the level of d -serine. The SAW-biosensor is based on the utilization of an inactivated form of the d -serine dehydratase isolated from Saccharomyces cerevisiae , a biomolecule that is able to specifically bind d -serine. In particular, we produced a PLP-reduced d -serine dehydratase biomolecule that was still able to bind d -serine and not to transform it into the product. The binding event between the “inactivated” d -serine dehydratase and d -serine was monitored by SAW delay-lines. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Sensors & Actuators B: Chemical is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.snb.2015.11.099
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      – Code: eng
        Text: English
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      – SubjectFull: Shear (Mechanics)
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      – SubjectFull: Surface acoustic wave sensors
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      – SubjectFull: Serine
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