Bibliographic Details
| Title: |
Prenatal lead exposure and fetal growth: Smaller infants have heightened susceptibility. |
| Authors: |
Rodosthenous, Rodosthenis S.1 rrodosth@hsph.harvard.edu, Burris, Heather H.1,2 heburris@bidmc.harvard.edu, Svensson, Katherine3 Katherine.svensson@mssm.edu, Amarasiriwardena, Chitra J.3 Chitra.amarasiriwardena@mssm.edu, Cantoral, Alejandra4 alejandra.cantoral@insp.mx, Schnaas, Lourdes4 lschnaas@hotmail.com, Mercado-García, Adriana4 adrianam@insp.mx, Coull, Brent A.1 bcoull@hsph.harvard.edu, Wright, Robert O.3 Robert.wright@mssm.edu, Téllez-Rojo, Martha M.4 mmtellez@insp.mx, Baccarelli, Andrea A.5 andrea.baccarelli@columbia.edu |
| Source: |
Environment International. Feb2017, Vol. 99, p228-233. 6p. |
| Subjects: |
Lead in the body, Fetal development, Infant health, Physiological effects of pollution, Disease susceptibility |
| Abstract: |
Background As population lead levels decrease, the toxic effects of lead may be distributed to more sensitive populations, such as infants with poor fetal growth. Objectives To determine the association of prenatal lead exposure and fetal growth; and to evaluate whether infants with poor fetal growth are more susceptible to lead toxicity than those with normal fetal growth. Methods We examined the association of second trimester maternal blood lead levels (BLL) with birthweight-for-gestational age (BWGA) z-score in 944 mother-infant participants of the PROGRESS cohort. We determined the association between maternal BLL and BWGA z-score by using both linear and quantile regression. We estimated odds ratios for small-for-gestational age (SGA) infants between maternal BLL quartiles using logistic regression. Maternal age, body mass index, socioeconomic status, parity, household smoking exposure, hemoglobin levels, and infant sex were included as confounders. Results While linear regression showed a negative association between maternal BLL and BWGA z-score ( β = − 0.06 z-score units per log 2 BLL increase; 95% CI: − 0.13, 0.003; P = 0.06), quantile regression revealed larger magnitudes of this association in the < 30th percentiles of BWGA z-score ( β range [− 0.08, − 0.13] z-score units per log 2 BLL increase; all P values < 0.05). Mothers in the highest BLL quartile had an odds ratio of 1.62 (95% CI: 0.99–2.65) for having a SGA infant compared to the lowest BLL quartile. Conclusions While both linear and quantile regression showed a negative association between prenatal lead exposure and birthweight, quantile regression revealed that smaller infants may represent a more susceptible subpopulation. [ABSTRACT FROM AUTHOR] |
|
Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Engineering Source |
