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Evaluation of Peritoneal Microbubble Oxygenation Therapy in a Rabbit Model of Hypoxemia.

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Title: Evaluation of Peritoneal Microbubble Oxygenation Therapy in a Rabbit Model of Hypoxemia.
Authors: Legband, Nathan D.1, Terry, Benjamin S.1, Feshitan, Jameel A.2, Borden, Mark A.2
Source: IEEE Transactions on Biomedical Engineering. May2015, Vol. 62 Issue 5, p1376-1382. 7p.
Subjects: Lung injury treatment, Hypoxemia, Respiratory distress syndrome, Respiratory obstructions, Impaired oxygen delivery
Abstract: Alternative extrapulmonary oxygenation technologies are needed to treat patients suffering from severe hypoxemia refractory to mechanical ventilation. We previously demonstrated that peritoneal microbubble oxygenation (PMO), in which phospholipid-coated oxygen microbubbles (OMBs) are delivered into the peritoneal cavity, can successfully oxygenate rats suffering from a right pneumothorax. This study addressed the need to scale up the procedure to a larger animal with a splanchnic cardiac output similar to humans. Our results show that PMO therapy can double the survival time of rabbits experiencing complete tracheal occlusion from 6.6 ± 0.6 min for the saline controls to 12.2 ± 3.0 min for the bolus PMO-treated cohort. Additionally, we designed and tested a new peritoneal delivery system to circulate OMBs through the peritoneal cavity. Circulation achieved a similar survival benefit to bolus delivery under these conditions. Overall, these results support the feasibility of the PMO technology to provide extrapulmonary ventilation for rescue of severely hypoxic patients. [ABSTRACT FROM PUBLISHER]
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Database: Engineering Source
Description
Abstract:Alternative extrapulmonary oxygenation technologies are needed to treat patients suffering from severe hypoxemia refractory to mechanical ventilation. We previously demonstrated that peritoneal microbubble oxygenation (PMO), in which phospholipid-coated oxygen microbubbles (OMBs) are delivered into the peritoneal cavity, can successfully oxygenate rats suffering from a right pneumothorax. This study addressed the need to scale up the procedure to a larger animal with a splanchnic cardiac output similar to humans. Our results show that PMO therapy can double the survival time of rabbits experiencing complete tracheal occlusion from 6.6 ± 0.6 min for the saline controls to 12.2 ± 3.0 min for the bolus PMO-treated cohort. Additionally, we designed and tested a new peritoneal delivery system to circulate OMBs through the peritoneal cavity. Circulation achieved a similar survival benefit to bolus delivery under these conditions. Overall, these results support the feasibility of the PMO technology to provide extrapulmonary ventilation for rescue of severely hypoxic patients. [ABSTRACT FROM PUBLISHER]
ISSN:00189294
DOI:10.1109/TBME.2015.2388611