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Bone susceptibility mapping with MRI is an alternative and reliable biomarker of osteoporosis in postmenopausal women.

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Title: Bone susceptibility mapping with MRI is an alternative and reliable biomarker of osteoporosis in postmenopausal women.
Authors: Chen, Yanjun1, Guo, Yihao2, Zhang, Xintao1, Mei, Yingjie3, Feng, Yanqiu2 foree@163.com, Zhang, Xiaodong1 ddautumn@126.com
Source: European Radiology. Dec2018, Vol. 28 Issue 12, p5027-5034. 8p. 1 Diagram, 2 Charts, 3 Graphs.
Subjects: Osteoporosis, Osteoporosis in women, Postmenopause, Computed tomography, Biological tags, Bone fracture prevention, Longitudinal method, Lumbar vertebrae, Magnetic resonance imaging, Research funding, Bone density
Abstract: Objectives: To investigate the efficacy of quantitative susceptibility mapping (QSM) in the assessment of osteoporosis for postmenopausal women.Methods: Between May and September 2017, a total of 70 postmenopausal women who underwent MRI-based QSM and quantitative computed tomography (QCT) were consecutively enrolled in this prospective study. The measurement of QSM and QCT values was performed on the L3 vertebrae body. On the basis of QCT value, all individuals were divided into three groups (normal, osteopenia and osteoporosis).Results: On the basis of QCT, 18 individuals were normal (25.7%), 26 osteopenic (37.1%) and 26 osteoporotic (37.1%). The QSM value was age-related (p = 0.04) and significantly higher in the osteoporosis group than in either the normal or osteopenia group (for all, p < 0.001). In addition, the QSM value was highly correlated with QCT value (r = - 0.720, p < 0.001). For QSM, the area under the curve (AUC), sensitivity and specificity for differentiating osteopenia from non-osteopenia were 0.88, 86.5% and 77.8%, respectively, and for differentiating osteoporosis from non-osteoporosis they were 0.86, 80.8% and 77.3%, respectively.Conclusions: MRI-based QSM could be used for quantifying susceptibility in vertebrae and has the potential to be a new biomarker in the assessment of osteoporosis for postmenopausal women.Key Points: • Osteoporosis significantly increases risk of fracture for postmenopausal women. • QSM value was correlated with QCT value (r = - 0.72, p < 0.001). • QSM is feasible in the assessment of osteoporosis for postmenopausal women. • QSM offers the quantification of susceptibility within bone. [ABSTRACT FROM AUTHOR]
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Abstract:<bold>Objectives: </bold>To investigate the efficacy of quantitative susceptibility mapping (QSM) in the assessment of osteoporosis for postmenopausal women.<bold>Methods: </bold>Between May and September 2017, a total of 70 postmenopausal women who underwent MRI-based QSM and quantitative computed tomography (QCT) were consecutively enrolled in this prospective study. The measurement of QSM and QCT values was performed on the L3 vertebrae body. On the basis of QCT value, all individuals were divided into three groups (normal, osteopenia and osteoporosis).<bold>Results: </bold>On the basis of QCT, 18 individuals were normal (25.7%), 26 osteopenic (37.1%) and 26 osteoporotic (37.1%). The QSM value was age-related (p = 0.04) and significantly higher in the osteoporosis group than in either the normal or osteopenia group (for all, p < 0.001). In addition, the QSM value was highly correlated with QCT value (r = - 0.720, p < 0.001). For QSM, the area under the curve (AUC), sensitivity and specificity for differentiating osteopenia from non-osteopenia were 0.88, 86.5% and 77.8%, respectively, and for differentiating osteoporosis from non-osteoporosis they were 0.86, 80.8% and 77.3%, respectively.<bold>Conclusions: </bold>MRI-based QSM could be used for quantifying susceptibility in vertebrae and has the potential to be a new biomarker in the assessment of osteoporosis for postmenopausal women.<bold>Key Points: </bold>• Osteoporosis significantly increases risk of fracture for postmenopausal women. • QSM value was correlated with QCT value (r = - 0.72, p < 0.001). • QSM is feasible in the assessment of osteoporosis for postmenopausal women. • QSM offers the quantification of susceptibility within bone. [ABSTRACT FROM AUTHOR]
ISSN:09387994
DOI:10.1007/s00330-018-5419-x