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Exploring neutron capture therapy with 33S and 10B.

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Title: Exploring neutron capture therapy with 33S and 10B.
Authors: López-Casas, I.1 (AUTHOR), Praena, J.1 (AUTHOR) jpraena@ugr.es, Arias de Saavedra, F.1 (AUTHOR), Sabaté-Gilarte, M.2,3 (AUTHOR), Porras, I.1 (AUTHOR)
Source: Applied Radiation & Isotopes. Sep2020, Vol. 163, pN.PAG-N.PAG. 1p.
Subjects: Neutron capture, European Organization for Nuclear Research, Silicon isotopes, Neutron beams, Neutron spectroscopy, Neutron sources, Neutrons
Geographic Terms: Delhi (India)
Abstract: The 33S(n,α)30Si reaction was proposed as cooperative neutron capturer to 10B(n,α)7Li in Neutron Capture Therapy (NCT). At that moment, the available 33S(n,α)30Si cross-section data were scarce and discrepant in key energy ranges for its use in NCT. Since then, three experiments have been carried out at n_TOF facility at CERN and at Institut Laue-Langevin. These new data are used for the calculation of the dose rate on ICRU-4 tissue by using kerma factors, a simplified model of tissue and a 13.45 keV neutron beam, energy of the most important 33S(n,α)30Si resonance. A significant enhancement of the dose rate due to the presence of 33S is shown. In spite of the limitations, the cooperative action of 33S and 10B is an interesting possibility to be studied for accelerator-based neutron sources with non-moderated neutrons. • 33S as neutron capturer in BNCT. • New data on the 33S(n, α) 30Si reaction. • Simulations of the dose rate. • Comparison between 10B and 33S and combined effect. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:The 33S(n,α)30Si reaction was proposed as cooperative neutron capturer to 10B(n,α)7Li in Neutron Capture Therapy (NCT). At that moment, the available 33S(n,α)30Si cross-section data were scarce and discrepant in key energy ranges for its use in NCT. Since then, three experiments have been carried out at n_TOF facility at CERN and at Institut Laue-Langevin. These new data are used for the calculation of the dose rate on ICRU-4 tissue by using kerma factors, a simplified model of tissue and a 13.45 keV neutron beam, energy of the most important 33S(n,α)30Si resonance. A significant enhancement of the dose rate due to the presence of 33S is shown. In spite of the limitations, the cooperative action of 33S and 10B is an interesting possibility to be studied for accelerator-based neutron sources with non-moderated neutrons. • 33S as neutron capturer in BNCT. • New data on the 33S(n, α) 30Si reaction. • Simulations of the dose rate. • Comparison between 10B and 33S and combined effect. [ABSTRACT FROM AUTHOR]
ISSN:09698043
DOI:10.1016/j.apradiso.2020.109220