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Fluorescent detection of dipicolinic acid as a biomarker in bacterial spores employing terbium ion-coordinated magnetite nanoparticles.

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Title: Fluorescent detection of dipicolinic acid as a biomarker in bacterial spores employing terbium ion-coordinated magnetite nanoparticles.
Authors: Koo, Thomas Myeongseok1 (AUTHOR), Ko, Min Jun1 (AUTHOR), Park, Bum Chul1,2 (AUTHOR), Kim, Myeong Soo3 (AUTHOR), Kim, Young Keun1,2,3 (AUTHOR) ykim97@korea.ac.kr
Source: Journal of Hazardous Materials. Apr2021, Vol. 408, pN.PAG-N.PAG. 1p.
Subjects: Terbium, Bacterial spores, Magnetite, Nanoparticles, Magnetics, Detection limit, Chemical stability
Abstract: Anthrax is a bioterror agent because of its toxicity and the tolerance of its bacterial spores. Thus, researchers have attempted to develop various nanomaterials to detect dipicolinic acid (DPA), a biomarker of bacterial spores. Nanomaterials containing lanthanide ions have received considerable attention, owing to their potential to exhibit high sensitivity and selectivity in the detection of DPA via chelation with molecules. However, the fluorescent signals of the lanthanide complex are quenchable because the nanomaterials simultaneously absorb the excitation and emission light. For the precise detection of DPA, pure signals have to be obtained from the complex by alleviating the quenching effect of the nanomaterials. In this study, we develop a structure with terbium ion (Tb3+)-coordinated magnetite (Fe 3 O 4) nanoparticle to detect DPA. Tb3+ can be detached from the magnetite during chelation with the DPA, and the complex can emit the unencumbered signals with improved detection limit through the application of a magnetic field. The detection system exhibits a significantly lower detection limit (5.4 nM) than the infectious dosage of anthrax (60 μM) with high selectivity and chemical stability. This study informs the improvement of detection limits via the separation of nanomaterials and lanthanide complex. ga1 • Design of terbium (Tb) ion-coordinated magnetite (Fe 3 O 4) nanoparticles. • Tb ion is detached from magnetite and chelated with dipicolinic acid simultaneously. • Facile approach to detect unencumbered-fluorescent signal applying a magnetic field. • Low detection limit of 5.4 nM with high selectivity. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Hazardous Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 148774547
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Fluorescent detection of dipicolinic acid as a biomarker in bacterial spores employing terbium ion-coordinated magnetite nanoparticles.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Koo%2C+Thomas+Myeongseok%22">Koo, Thomas Myeongseok</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ko%2C+Min+Jun%22">Ko, Min Jun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Bum+Chul%22">Park, Bum Chul</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Myeong+Soo%22">Kim, Myeong Soo</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Young+Keun%22">Kim, Young Keun</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> ykim97@korea.ac.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Hazardous+Materials%22">Journal of Hazardous Materials</searchLink>. Apr2021, Vol. 408, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Terbium%22">Terbium</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+spores%22">Bacterial spores</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetite%22">Magnetite</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetics%22">Magnetics</searchLink><br /><searchLink fieldCode="DE" term="%22Detection+limit%22">Detection limit</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+stability%22">Chemical stability</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Anthrax is a bioterror agent because of its toxicity and the tolerance of its bacterial spores. Thus, researchers have attempted to develop various nanomaterials to detect dipicolinic acid (DPA), a biomarker of bacterial spores. Nanomaterials containing lanthanide ions have received considerable attention, owing to their potential to exhibit high sensitivity and selectivity in the detection of DPA via chelation with molecules. However, the fluorescent signals of the lanthanide complex are quenchable because the nanomaterials simultaneously absorb the excitation and emission light. For the precise detection of DPA, pure signals have to be obtained from the complex by alleviating the quenching effect of the nanomaterials. In this study, we develop a structure with terbium ion (Tb3+)-coordinated magnetite (Fe 3 O 4) nanoparticle to detect DPA. Tb3+ can be detached from the magnetite during chelation with the DPA, and the complex can emit the unencumbered signals with improved detection limit through the application of a magnetic field. The detection system exhibits a significantly lower detection limit (5.4 nM) than the infectious dosage of anthrax (60 μM) with high selectivity and chemical stability. This study informs the improvement of detection limits via the separation of nanomaterials and lanthanide complex. ga1 • Design of terbium (Tb) ion-coordinated magnetite (Fe 3 O 4) nanoparticles. • Tb ion is detached from magnetite and chelated with dipicolinic acid simultaneously. • Facile approach to detect unencumbered-fluorescent signal applying a magnetic field. • Low detection limit of 5.4 nM with high selectivity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Hazardous Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jhazmat.2020.124870
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Terbium
        Type: general
      – SubjectFull: Bacterial spores
        Type: general
      – SubjectFull: Magnetite
        Type: general
      – SubjectFull: Nanoparticles
        Type: general
      – SubjectFull: Magnetics
        Type: general
      – SubjectFull: Detection limit
        Type: general
      – SubjectFull: Chemical stability
        Type: general
    Titles:
      – TitleFull: Fluorescent detection of dipicolinic acid as a biomarker in bacterial spores employing terbium ion-coordinated magnetite nanoparticles.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Koo, Thomas Myeongseok
      – PersonEntity:
          Name:
            NameFull: Ko, Min Jun
      – PersonEntity:
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            NameFull: Park, Bum Chul
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            NameFull: Kim, Myeong Soo
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            NameFull: Kim, Young Keun
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            – D: 15
              M: 04
              Text: Apr2021
              Type: published
              Y: 2021
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            – Type: issn-print
              Value: 03043894
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            – Type: volume
              Value: 408
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            – TitleFull: Journal of Hazardous Materials
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