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Biomimetic chitosan-derived bifunctional lubricant with superior antibacterial and hydration lubrication performances.

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Title: Biomimetic chitosan-derived bifunctional lubricant with superior antibacterial and hydration lubrication performances.
Authors: Yang, Lumin1,2 (AUTHOR), Zhao, Xiaoduo1,3 (AUTHOR), Liao, Xiaozhu4 (AUTHOR), Wang, Rui1,3 (AUTHOR), Fan, Zengjie4 (AUTHOR), Ma, Shuanhong1,3 (AUTHOR) mashuanhong@licp.cas.cn, Zhou, Feng1 (AUTHOR) zhouf@licp.cas.cn
Source: Journal of Colloid & Interface Science. Jan2023:Part B, Vol. 629, p859-870. 12p.
Subjects: Infectious arthritis, Artificial joints, Articular cartilage, Peptides, Lubrication & lubricants, Polysaccharides
Abstract: Novel chitosan-derived biolubricant (CS-MPC-N) with both anti-bacterial and lubrication functions. [Display omitted] The lubrication deficiency in joints is a major cause of osteoarthritis. One of the most commonly used treatment means is to inject artificial lubricants, but there is a potential risk of infection during the injection process. Therefore, developing artificial lubricants with dual functions of friction-reduction and antibacterial is urgent. In this work, a novel polysaccharide-derived lubricant with simultaneous anti-bacteria and water-lubrication properties, called CS-MPC-N, is developed by grafting 2‑methacryloyloxylethyl phosphorylcholine (MPC) and nisin peptide onto backbone of chitosan (CS). Compared to the control CS, CS-MPC-N exhibits good lubrication and friction-reduction properties because of its excellent water solubility. Especially, CS-MPC-N shows low friction coefficient (0.03 ∼ 0.05) at the sliding interfaces of artificial joints materials or even natural articular cartilages. Moreover, CS-MPC-N can effectively inhibit the proliferation of Staphylococcus aureu, exhibiting excellent antibacterial effect. This kind of novel polysaccharide-derived lubricant is expected to be used in treating infectious arthritis. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Novel chitosan-derived biolubricant (CS-MPC-N) with both anti-bacterial and lubrication functions. [Display omitted] The lubrication deficiency in joints is a major cause of osteoarthritis. One of the most commonly used treatment means is to inject artificial lubricants, but there is a potential risk of infection during the injection process. Therefore, developing artificial lubricants with dual functions of friction-reduction and antibacterial is urgent. In this work, a novel polysaccharide-derived lubricant with simultaneous anti-bacteria and water-lubrication properties, called CS-MPC-N, is developed by grafting 2‑methacryloyloxylethyl phosphorylcholine (MPC) and nisin peptide onto backbone of chitosan (CS). Compared to the control CS, CS-MPC-N exhibits good lubrication and friction-reduction properties because of its excellent water solubility. Especially, CS-MPC-N shows low friction coefficient (0.03 ∼ 0.05) at the sliding interfaces of artificial joints materials or even natural articular cartilages. Moreover, CS-MPC-N can effectively inhibit the proliferation of Staphylococcus aureu, exhibiting excellent antibacterial effect. This kind of novel polysaccharide-derived lubricant is expected to be used in treating infectious arthritis. [ABSTRACT FROM AUTHOR]
ISSN:00219797
DOI:10.1016/j.jcis.2022.09.098