Bibliographic Details
| Title: |
Automated dynamic inlet microfluidics system: 3D printer adaptation for cost-effective, low volume, on-demand multi-analyte droplet generator. |
| Authors: |
Zia, Abdul Basit1 abdulbasit.zia@ubc.ca, Farrell, Justin1, Foulds, Ian G.1 |
| Source: |
Lab on a Chip. 6/7/2024, Vol. 24 Issue 11, p3015-3026. 12p. |
| Subjects: |
Microfluidics, Fused deposition modeling, 3-D printers, Library storage centers, Inlets |
| Geographic Terms: |
Cabo Verde |
| Abstract: |
The paper demonstrates an adaptation of a 3D printer (Prusa Mini+) with novel modules to develop a droplet generation system that generates combinatorial droplets from a standard 96 well plate. The calibration methodology developed would allow any fused deposition modeling (FDM) printer to generate monodisperse droplets (coefficient of variance (CV%) < 5%) from well plates or vials of any geometry. The system maintains precision across various volumes while maintaining a C.V. range of 0.81% to 3.61%, with an increased precision for larger volumes. The cost of the system developed is 70% less than commercially available droplet generation packages. Successful droplet library storage is accomplished via 3D printed cartridge connectors. The implemented system has been calibrated for Tygon® and PTFE at different velocities and volumetric configurations. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
