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Automated dynamic inlet microfluidics system: 3D printer adaptation for cost-effective, low volume, on-demand multi-analyte droplet generator.

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Title: Automated dynamic inlet microfluidics system: 3D printer adaptation for cost-effective, low volume, on-demand multi-analyte droplet generator.
Authors: Zia, Abdul Basit1 abdulbasit.zia@ubc.ca, Farrell, Justin1, Foulds, Ian G.1
Source: Lab on a Chip. 6/7/2024, Vol. 24 Issue 11, p3015-3026. 12p.
Subjects: Microfluidics, Fused deposition modeling, 3-D printers, Library storage centers, Inlets
Geographic Terms: Cabo Verde
Abstract: The paper demonstrates an adaptation of a 3D printer (Prusa Mini+) with novel modules to develop a droplet generation system that generates combinatorial droplets from a standard 96 well plate. The calibration methodology developed would allow any fused deposition modeling (FDM) printer to generate monodisperse droplets (coefficient of variance (CV%) < 5%) from well plates or vials of any geometry. The system maintains precision across various volumes while maintaining a C.V. range of 0.81% to 3.61%, with an increased precision for larger volumes. The cost of the system developed is 70% less than commercially available droplet generation packages. Successful droplet library storage is accomplished via 3D printed cartridge connectors. The implemented system has been calibrated for Tygon® and PTFE at different velocities and volumetric configurations. [ABSTRACT FROM AUTHOR]
Copyright of Lab on a Chip is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubType: Academic Journal
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  Data: The paper demonstrates an adaptation of a 3D printer (Prusa Mini+) with novel modules to develop a droplet generation system that generates combinatorial droplets from a standard 96 well plate. The calibration methodology developed would allow any fused deposition modeling (FDM) printer to generate monodisperse droplets (coefficient of variance (CV%) &lt; 5%) from well plates or vials of any geometry. The system maintains precision across various volumes while maintaining a C.V. range of 0.81% to 3.61%, with an increased precision for larger volumes. The cost of the system developed is 70% less than commercially available droplet generation packages. Successful droplet library storage is accomplished via 3D printed cartridge connectors. The implemented system has been calibrated for Tygon&#174; and PTFE at different velocities and volumetric configurations. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Lab on a Chip is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1039/d4lc00075g
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      – Code: eng
        Text: English
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      – SubjectFull: Microfluidics
        Type: general
      – SubjectFull: Fused deposition modeling
        Type: general
      – SubjectFull: 3-D printers
        Type: general
      – SubjectFull: Library storage centers
        Type: general
      – SubjectFull: Inlets
        Type: general
      – SubjectFull: Cabo Verde
        Type: general
    Titles:
      – TitleFull: Automated dynamic inlet microfluidics system: 3D printer adaptation for cost-effective, low volume, on-demand multi-analyte droplet generator.
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          Name:
            NameFull: Zia, Abdul Basit
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            NameFull: Farrell, Justin
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            NameFull: Foulds, Ian G.
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            – D: 07
              M: 06
              Text: 6/7/2024
              Type: published
              Y: 2024
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