Joint modeling of longitudinal health-related quality of life during concurrent chemoradiotherapy period and long-term survival among patients with advanced nasopharyngeal carcinoma.
Saved in:
| Title: | Joint modeling of longitudinal health-related quality of life during concurrent chemoradiotherapy period and long-term survival among patients with advanced nasopharyngeal carcinoma. |
|---|---|
| Authors: | Li, Ji-Bin1,2 (AUTHOR), Guo, Shan-Shan2,3 (AUTHOR), Liu, Ting2,3 (AUTHOR), Lin, Zhuo-Chen4 (AUTHOR), Gong, Wei-Jie5 (AUTHOR), Tang, Lin-Quan2,3 (AUTHOR), Guo, Ling2,3 (AUTHOR), Mo, Hao-Yuan2,3 (AUTHOR), Mai, Hai-Qiang2,3 (AUTHOR), Chen, Qiu-Yan2,3 (AUTHOR) chenqy@sysucc.org.cn |
| Source: | Radiation Oncology. 9/20/2024, Vol. 19 Issue 1, p1-7. 7p. |
| Subjects: | Psychotherapy, Appetite loss, Quality of life, Nasopharynx cancer, Fatigue (Physiology) |
| Abstract: | Background: To investigate the prognosis of longitudinal health-related quality of life (HRQOL) during concurrent chemoradiotherapy (CCRT) on survival outcomes in patients with advanced nasopharyngeal carcinoma (NPC). Methods: During 2012–2014, 145 adult NPC patients with stage II-IVb NPC were investigated weekly using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORCT QLQ-C30) during their CCRT period. The effects of longitudinal trends of HRQOL on survival outcomes were estimated using joint modeling, and hazard ratios (HRs) with 95% confidence intervals (95% CIs) were reported as a 10-point increase in HRQOL scores. Results: After a median follow-up of 83.4 months, the multivariable models showed significant associations of longitudinal increasing scores in fatigue and appetite loss during the CCRT period with distant metastasis-free survival: 10-point increases in scores of fatigue and appetite loss domains during CCRT period were significantly associated with 75% (HR: 1.75, 95% CI: 1.01, 3.02; p = 0.047) and 59% (HR: 1.59, 95% CI: 1.09, 2.59; p = 0.018) increase in the risk of distant metastasis, respectively. The prognostic effects of the longitudinal HRQOL trend on overall survival and progress-free survival were statistically non-significant. Conclusion: Increases in fatigue and appetite loss of HRQOL during the CCRT period are significantly associated with high risks of distant metastasis in advanced NPC patients. Nutritional support and psychological intervention are warranted for NPC patients during the treatment period. [ABSTRACT FROM AUTHOR] |
| Copyright of Radiation Oncology is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 179789658 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Joint modeling of longitudinal health-related quality of life during concurrent chemoradiotherapy period and long-term survival among patients with advanced nasopharyngeal carcinoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Li%2C+Ji-Bin%22">Li, Ji-Bin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Shan-Shan%22">Guo, Shan-Shan</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Ting%22">Liu, Ting</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Zhuo-Chen%22">Lin, Zhuo-Chen</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gong%2C+Wei-Jie%22">Gong, Wei-Jie</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Lin-Quan%22">Tang, Lin-Quan</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Ling%22">Guo, Ling</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mo%2C+Hao-Yuan%22">Mo, Hao-Yuan</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mai%2C+Hai-Qiang%22">Mai, Hai-Qiang</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Qiu-Yan%22">Chen, Qiu-Yan</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> chenqy@sysucc.org.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Radiation+Oncology%22">Radiation Oncology</searchLink>. 9/20/2024, Vol. 19 Issue 1, p1-7. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Psychotherapy%22">Psychotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Appetite+loss%22">Appetite loss</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Nasopharynx+cancer%22">Nasopharynx cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Fatigue+%28Physiology%29%22">Fatigue (Physiology)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: To investigate the prognosis of longitudinal health-related quality of life (HRQOL) during concurrent chemoradiotherapy (CCRT) on survival outcomes in patients with advanced nasopharyngeal carcinoma (NPC). Methods: During 2012–2014, 145 adult NPC patients with stage II-IVb NPC were investigated weekly using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORCT QLQ-C30) during their CCRT period. The effects of longitudinal trends of HRQOL on survival outcomes were estimated using joint modeling, and hazard ratios (HRs) with 95% confidence intervals (95% CIs) were reported as a 10-point increase in HRQOL scores. Results: After a median follow-up of 83.4 months, the multivariable models showed significant associations of longitudinal increasing scores in fatigue and appetite loss during the CCRT period with distant metastasis-free survival: 10-point increases in scores of fatigue and appetite loss domains during CCRT period were significantly associated with 75% (HR: 1.75, 95% CI: 1.01, 3.02; p = 0.047) and 59% (HR: 1.59, 95% CI: 1.09, 2.59; p = 0.018) increase in the risk of distant metastasis, respectively. The prognostic effects of the longitudinal HRQOL trend on overall survival and progress-free survival were statistically non-significant. Conclusion: Increases in fatigue and appetite loss of HRQOL during the CCRT period are significantly associated with high risks of distant metastasis in advanced NPC patients. Nutritional support and psychological intervention are warranted for NPC patients during the treatment period. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Radiation Oncology is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=179789658 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13014-024-02473-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 1 Subjects: – SubjectFull: Psychotherapy Type: general – SubjectFull: Appetite loss Type: general – SubjectFull: Quality of life Type: general – SubjectFull: Nasopharynx cancer Type: general – SubjectFull: Fatigue (Physiology) Type: general Titles: – TitleFull: Joint modeling of longitudinal health-related quality of life during concurrent chemoradiotherapy period and long-term survival among patients with advanced nasopharyngeal carcinoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li, Ji-Bin – PersonEntity: Name: NameFull: Guo, Shan-Shan – PersonEntity: Name: NameFull: Liu, Ting – PersonEntity: Name: NameFull: Lin, Zhuo-Chen – PersonEntity: Name: NameFull: Gong, Wei-Jie – PersonEntity: Name: NameFull: Tang, Lin-Quan – PersonEntity: Name: NameFull: Guo, Ling – PersonEntity: Name: NameFull: Mo, Hao-Yuan – PersonEntity: Name: NameFull: Mai, Hai-Qiang – PersonEntity: Name: NameFull: Chen, Qiu-Yan IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 09 Text: 9/20/2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 1748717X Numbering: – Type: volume Value: 19 – Type: issue Value: 1 Titles: – TitleFull: Radiation Oncology Type: main |
| ResultId | 1 |
