Development of an analytical method for guazatine pesticides in agricultural products using LC-MS/MS.
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| Title: | Development of an analytical method for guazatine pesticides in agricultural products using LC-MS/MS. |
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| Authors: | Park, So Hee1 (AUTHOR), Oh, Dogyung1 (AUTHOR), Baek, Eun Joo1 (AUTHOR), Na, Tae Woong2 (AUTHOR) naratw@korea.kr |
| Source: | Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment. May2025, Vol. 42 Issue 5, p594-602. 9p. |
| Subjects: | Farm produce, Microbiological synthesis, Lipid synthesis, Matrix effect, Standard deviations |
| Abstract: | Guazatine, a non-invasive disinfectant used for seed treatment and post-harvest citrus protection, inhibits bacterial lipid synthesis and consists of about 13 components. While it may occasionally be detected in fruits and vegetables such as citrus, its use as a pesticide has been banned in several countries due to health and environmental concerns. To ensure safe export of domestic produce, a simultaneous method of analysis for guazatine components was developed, focusing on GG, GGG, GGN, and GNG as indicators. Using LC-MS/MS, samples were extracted with a 3% formic acid/acetone mixture and purified with hexane. The method was validated across five agricultural products (mandarin, pepper, potato, brown rice, and soybean), achieving an r2 above 0.995, and detection and quantitation limits of 0.8 and 2.5 µg/L, respectively. Ion suppression was high, with matrix effects ranging from −84.2 to −89.8%. Recovery rates were 70.2–99.6%, with relative standard deviations under 6.8%. Cross-laboratory validation showed recovery rates of 70.3–106.7% and relative standard deviations below 15.0%, meeting CODEX guidelines. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Guazatine, a non-invasive disinfectant used for seed treatment and post-harvest citrus protection, inhibits bacterial lipid synthesis and consists of about 13 components. While it may occasionally be detected in fruits and vegetables such as citrus, its use as a pesticide has been banned in several countries due to health and environmental concerns. To ensure safe export of domestic produce, a simultaneous method of analysis for guazatine components was developed, focusing on GG, GGG, GGN, and GNG as indicators. Using LC-MS/MS, samples were extracted with a 3% formic acid/acetone mixture and purified with hexane. The method was validated across five agricultural products (mandarin, pepper, potato, brown rice, and soybean), achieving an r2 above 0.995, and detection and quantitation limits of 0.8 and 2.5 µg/L, respectively. Ion suppression was high, with matrix effects ranging from −84.2 to −89.8%. Recovery rates were 70.2–99.6%, with relative standard deviations under 6.8%. Cross-laboratory validation showed recovery rates of 70.3–106.7% and relative standard deviations below 15.0%, meeting CODEX guidelines. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 19440049 |
| DOI: | 10.1080/19440049.2025.2467625 |
