View in EDS HTML Full Text PDF Full Text

Characterization and chemical modification of a Bacillus velezensis SN-1 exopolysaccharide, rEPS-2.

Saved in:
Bibliographic Details
Title: Characterization and chemical modification of a Bacillus velezensis SN-1 exopolysaccharide, rEPS-2.
Authors: Wu, Rina1 (AUTHOR) wrn6956@163.com, Liu, Yao2 (AUTHOR) liuyao2605@163.com, Gao, Yuzhe2 (AUTHOR), Yang, Xiaofei2 (AUTHOR), Yang, Qingyu2 (AUTHOR) yangqy0311@163.com, Cao, Chengxu2 (AUTHOR) caochengxu@synu.edu.cn
Source: European Food Research & Technology. Aug2025, Vol. 251 Issue 8, p2161-2171. 11p.
Subjects: Microbial polysaccharides, Cancer treatment, Oxidant status, Chemical engineering, Antioxidants, Structure-activity relationships
Abstract: This study developed three structurally modified derivatives (acetylated rEPS-2 A, phosphorylated rEPS-2P, and carboxymethylated rEPS-2 C) from rEPS-2, a bioactive exopolysaccharide produced by Bacillus velezensis SN-1. Comprehensive characterization using gel permeation chromatography, FT-IR, and NMR spectroscopy confirmed successful functional group incorporation, while SEM and TGA analyses revealed significant alterations in surface morphology and thermal stability. Biological evaluation demonstrated that carboxymethylated rEPS-2 C exhibited markedly enhanced antioxidant capacity (showing 28.6% increase in DPPH scavenging activity compared to native rEPS-2) and superior antitumor effects (with 75.35% inhibition against HepG-2 cells), outperforming other derivatives. These findings highlight the structure-activity relationship of polysaccharide modifications and position rEPS-2 C as a promising dual-functional agent for oxidative stress-related disorders and cancer therapy applications. [ABSTRACT FROM AUTHOR]
Copyright of European Food Research & Technology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 187625006
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Characterization and chemical modification of a Bacillus velezensis SN-1 exopolysaccharide, rEPS-2.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Wu%2C+Rina%22">Wu, Rina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> wrn6956@163.com</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Yao%22">Liu, Yao</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> liuyao2605@163.com</i><br /><searchLink fieldCode="AR" term="%22Gao%2C+Yuzhe%22">Gao, Yuzhe</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Xiaofei%22">Yang, Xiaofei</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Qingyu%22">Yang, Qingyu</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> yangqy0311@163.com</i><br /><searchLink fieldCode="AR" term="%22Cao%2C+Chengxu%22">Cao, Chengxu</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> caochengxu@synu.edu.cn</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Food+Research+%26+Technology%22">European Food Research & Technology</searchLink>. Aug2025, Vol. 251 Issue 8, p2161-2171. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Microbial+polysaccharides%22">Microbial polysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidant+status%22">Oxidant status</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+engineering%22">Chemical engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Structure-activity+relationships%22">Structure-activity relationships</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study developed three structurally modified derivatives (acetylated rEPS-2 A, phosphorylated rEPS-2P, and carboxymethylated rEPS-2 C) from rEPS-2, a bioactive exopolysaccharide produced by Bacillus velezensis SN-1. Comprehensive characterization using gel permeation chromatography, FT-IR, and NMR spectroscopy confirmed successful functional group incorporation, while SEM and TGA analyses revealed significant alterations in surface morphology and thermal stability. Biological evaluation demonstrated that carboxymethylated rEPS-2 C exhibited markedly enhanced antioxidant capacity (showing 28.6% increase in DPPH scavenging activity compared to native rEPS-2) and superior antitumor effects (with 75.35% inhibition against HepG-2 cells), outperforming other derivatives. These findings highlight the structure-activity relationship of polysaccharide modifications and position rEPS-2 C as a promising dual-functional agent for oxidative stress-related disorders and cancer therapy applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Food Research & Technology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=187625006
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00217-025-04748-4
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 2161
    Subjects:
      – SubjectFull: Microbial polysaccharides
        Type: general
      – SubjectFull: Cancer treatment
        Type: general
      – SubjectFull: Oxidant status
        Type: general
      – SubjectFull: Chemical engineering
        Type: general
      – SubjectFull: Antioxidants
        Type: general
      – SubjectFull: Structure-activity relationships
        Type: general
    Titles:
      – TitleFull: Characterization and chemical modification of a Bacillus velezensis SN-1 exopolysaccharide, rEPS-2.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wu, Rina
      – PersonEntity:
          Name:
            NameFull: Liu, Yao
      – PersonEntity:
          Name:
            NameFull: Gao, Yuzhe
      – PersonEntity:
          Name:
            NameFull: Yang, Xiaofei
      – PersonEntity:
          Name:
            NameFull: Yang, Qingyu
      – PersonEntity:
          Name:
            NameFull: Cao, Chengxu
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 14382377
          Numbering:
            – Type: volume
              Value: 251
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: European Food Research & Technology
              Type: main
ResultId 1