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Deuteron-induced nuclear reactions to produce 177Lu: Extension of cross-sections data up to 33 MeV and impact on purity.

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Title: Deuteron-induced nuclear reactions to produce 177Lu: Extension of cross-sections data up to 33 MeV and impact on purity.
Authors: López-Melero, E.1 (AUTHOR) melopez@ugr.es, Nigron, E.2 (AUTHOR), Haddad, F.2,3 (AUTHOR), Praena, J.1 (AUTHOR)
Source: Applied Radiation & Isotopes. Jan2026, Vol. 227, pN.PAG-N.PAG. 1p.
Subjects: Deuteron reactions, Radioisotopes, Metastable states, Isotope separation, Nuclear activation analysis, Gamma ray spectrometry, Nuclear medicine
Abstract: Activation cross-sections of lutetium and ytterbium radionuclides have been measured by deuteron-induced nuclear reaction on n a t Yb(d,x) at the GIP ARRONAX (Saint-Herblain, France) cyclotron facility with a beam energy up to 33 MeV using the stacked-foil activation technique combined with high resolution γ -ray spectrometry. The measured experimental values enable the extension of the cross-section to higher energies. As a primary objective, we have focused on the cumulative measurement of the direct and indirect production routes of the therapeutic radioisotope 177 g Lu, via 176Yb(d,n) 177 g , m Lu and 176Yb(d,p) 177Yb → 177 g Lu respectively. Post-irradiation gamma analysis, including a long gamma counting period, was performed to calculate the yield of the undesirable metastable isotopic impurity 177 m Lu. The results showed that it was found to be lower than our detection limit i.e. < 0.0005% of 177 g Lu yield. Thick target yields for all detected radionuclides are also calculated in this paper. These measurements enabled the estimation of the production yield and isotopic purity of 177Lu obtained via deuteron-induced nuclear reactions for large production batches using highly enriched 176Yb 2 O 3 samples (> 99.5%). • Cross-section measurement of the theranostic radioisotope 177Lu induced by deuterons up to 33 MeV. • Metastable impurity 177 m Lu below the detection limit (< 0.0005% of 177 g Lu yield). • Production yields and isotopic purities estimated from enriched 176Yb 2 O 3 samples (> 99.5%). [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Activation cross-sections of lutetium and ytterbium radionuclides have been measured by deuteron-induced nuclear reaction on n a t Yb(d,x) at the GIP ARRONAX (Saint-Herblain, France) cyclotron facility with a beam energy up to 33 MeV using the stacked-foil activation technique combined with high resolution γ -ray spectrometry. The measured experimental values enable the extension of the cross-section to higher energies. As a primary objective, we have focused on the cumulative measurement of the direct and indirect production routes of the therapeutic radioisotope 177 g Lu, via 176Yb(d,n) 177 g , m Lu and 176Yb(d,p) 177Yb → 177 g Lu respectively. Post-irradiation gamma analysis, including a long gamma counting period, was performed to calculate the yield of the undesirable metastable isotopic impurity 177 m Lu. The results showed that it was found to be lower than our detection limit i.e. < 0.0005% of 177 g Lu yield. Thick target yields for all detected radionuclides are also calculated in this paper. These measurements enabled the estimation of the production yield and isotopic purity of 177Lu obtained via deuteron-induced nuclear reactions for large production batches using highly enriched 176Yb 2 O 3 samples (> 99.5%). • Cross-section measurement of the theranostic radioisotope 177Lu induced by deuterons up to 33 MeV. • Metastable impurity 177 m Lu below the detection limit (< 0.0005% of 177 g Lu yield). • Production yields and isotopic purities estimated from enriched 176Yb 2 O 3 samples (> 99.5%). [ABSTRACT FROM AUTHOR]
ISSN:09698043
DOI:10.1016/j.apradiso.2025.112263