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Comprehensive 4D Parallel Transmission Spatial‐Spectral Pulse Design for Slab‐Selective Uniform Water‐Selective Excitation: Demonstration in the Human Brain at 7 Tesla.

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Title: Comprehensive 4D Parallel Transmission Spatial‐Spectral Pulse Design for Slab‐Selective Uniform Water‐Selective Excitation: Demonstration in the Human Brain at 7 Tesla.
Authors: Shao, Xin1 (AUTHOR), Zhang, Zhe2 (AUTHOR), Zhong, Wen1 (AUTHOR), Guo, Hua1 (AUTHOR) huaguo@tsinghua.edu.cn, Ugurbil, Kamil3 (AUTHOR), Wu, Xiaoping3 (AUTHOR)
Source: Magnetic Resonance in Medicine. Apr2026, Vol. 95 Issue 4, p2052-2062. 11p.
Subjects: Functional magnetic resonance imaging, Magnetic resonance imaging, Electronic pulse techniques, Diagnostic imaging
Abstract: Purpose: To propose a new parallel transmission (pTx) spatial‐spectral (SPSP) pulse design for achieving slab‐selective uniform water‐selective excitation without unwanted out‐of‐slab fat excitation when using bipolar slab‐selective gradients to maintain a sharp slab profile. Methods: Our new pTx SPSP pulses were designed by formulating the design problem comprehensively in the 4D space (1D spectral and 3D spatial domains) and by incorporating a SPINS‐like 2D excitation k‐space trajectory for within‐slab flip‐angle homogenization. Our new design was validated at 7 T using simulation, phantom and human experiments with the commercial Nova eight‐channel transmit RF head coil. Its utility was demonstrated by comparing to traditional multi‐spoke pTx SPSP pulses. Results: In both simulation and experiments, our design outperformed traditional approaches, producing slab‐selective uniform water‐selective excitation with no out‐of‐slab fat excitation. Quantitatively, coefficient of variation measuring excitation non‐uniformity reduced by up to ∼23%. Conclusion: Our proposed new design provides an effective solution for slab‐selective uniform water‐selective excitation, holding a promise to many applications including mesoscale BOLD fMRI and fat‐free body imaging at ultrahigh field. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Purpose: To propose a new parallel transmission (pTx) spatial‐spectral (SPSP) pulse design for achieving slab‐selective uniform water‐selective excitation without unwanted out‐of‐slab fat excitation when using bipolar slab‐selective gradients to maintain a sharp slab profile. Methods: Our new pTx SPSP pulses were designed by formulating the design problem comprehensively in the 4D space (1D spectral and 3D spatial domains) and by incorporating a SPINS‐like 2D excitation k‐space trajectory for within‐slab flip‐angle homogenization. Our new design was validated at 7 T using simulation, phantom and human experiments with the commercial Nova eight‐channel transmit RF head coil. Its utility was demonstrated by comparing to traditional multi‐spoke pTx SPSP pulses. Results: In both simulation and experiments, our design outperformed traditional approaches, producing slab‐selective uniform water‐selective excitation with no out‐of‐slab fat excitation. Quantitatively, coefficient of variation measuring excitation non‐uniformity reduced by up to ∼23%. Conclusion: Our proposed new design provides an effective solution for slab‐selective uniform water‐selective excitation, holding a promise to many applications including mesoscale BOLD fMRI and fat‐free body imaging at ultrahigh field. [ABSTRACT FROM AUTHOR]
ISSN:07403194
DOI:10.1002/mrm.70183