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A dual-channel smart fluorescent probe for rapid on-site detection of thiophenol and hydrazine in biological, environmental, and food samples.

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Title: A dual-channel smart fluorescent probe for rapid on-site detection of thiophenol and hydrazine in biological, environmental, and food samples.
Authors: Oguz, Mehmet1 (AUTHOR) m.oguz2011@gmail.com, Aydin, Duygu2 (AUTHOR), Malkondu, Sait3 (AUTHOR), Erdemir, Serkan1 (AUTHOR)
Source: Food Chemistry. Apr2026:Part B, Vol. 508, pN.PAG-N.PAG. 1p.
Subjects: Thiophenol, Hydrazine, On-site evaluation, Food safety, Environmental sampling, Biological specimens, Fluorescent probes, Cell imaging
Abstract: Thiophenol (PhSH) and hydrazine (N₂H₄) are widely present in industrial, agricultural, and food-related processes, posing significant risks to human health and environmental safety. In this study, we introduce INS (2-(benzo[ d ]thiazol-2-yl)-4-((1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl 2,4-dinitrobenzenesulfonate), a dual-responsive fluorescent probe capable of selectively distinguishing PhSH and N₂H₄ through reaction-triggered modulation of d -PET, ICT, and ESIPT processes. INS displays rapid responses (≤2 min for PhSH and ≤ 5 min for N₂H₄), high sensitivity with detection limits of 0.731 and 1.016 μM, respectively, and excellent selectivity. Mechanistic investigations using NMR, TOF-MS, and DFT analyses confirmed the distinct sensing pathways. The probe demonstrated strong applicability in real matrices, enabling quantitative detection of both analytes in soil and water with recoveries of 98.9–112.2%. Portable paper strip, cotton swab, and smartphone-assisted imaging further supported its suitability for on-site testing. Additionally, food sample analyse and live-cell imaging confirmed the biocompatibility and practical utility of INS for monitoring hazardous contaminants. [Display omitted] • A novel dual-emission fluorescent probe INS was developed for PhSH and N₂H₄. • INS enables simultaneous and discriminative sensing on a single molecular scaffold. • Distinct d -PET, ICT, and ESIPT pathways afford selective dual fluorescence outputs. • The probe offers ultrafast response, low LODs, and strong anti-interference ability. • INS demonstrated applicability in real samples, paper sensors, and live-cell imaging. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Thiophenol (PhSH) and hydrazine (N₂H₄) are widely present in industrial, agricultural, and food-related processes, posing significant risks to human health and environmental safety. In this study, we introduce INS (2-(benzo[ d ]thiazol-2-yl)-4-((1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl 2,4-dinitrobenzenesulfonate), a dual-responsive fluorescent probe capable of selectively distinguishing PhSH and N₂H₄ through reaction-triggered modulation of d -PET, ICT, and ESIPT processes. INS displays rapid responses (≤2 min for PhSH and ≤ 5 min for N₂H₄), high sensitivity with detection limits of 0.731 and 1.016 μM, respectively, and excellent selectivity. Mechanistic investigations using NMR, TOF-MS, and DFT analyses confirmed the distinct sensing pathways. The probe demonstrated strong applicability in real matrices, enabling quantitative detection of both analytes in soil and water with recoveries of 98.9–112.2%. Portable paper strip, cotton swab, and smartphone-assisted imaging further supported its suitability for on-site testing. Additionally, food sample analyse and live-cell imaging confirmed the biocompatibility and practical utility of INS for monitoring hazardous contaminants. [Display omitted] • A novel dual-emission fluorescent probe INS was developed for PhSH and N₂H₄. • INS enables simultaneous and discriminative sensing on a single molecular scaffold. • Distinct d -PET, ICT, and ESIPT pathways afford selective dual fluorescence outputs. • The probe offers ultrafast response, low LODs, and strong anti-interference ability. • INS demonstrated applicability in real samples, paper sensors, and live-cell imaging. [ABSTRACT FROM AUTHOR]
ISSN:03088146
DOI:10.1016/j.foodchem.2026.148540