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A dual-channel smart fluorescent probe for rapid on-site detection of thiophenol and hydrazine in biological, environmental, and food samples.

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Title: A dual-channel smart fluorescent probe for rapid on-site detection of thiophenol and hydrazine in biological, environmental, and food samples.
Authors: Oguz, Mehmet1 (AUTHOR) m.oguz2011@gmail.com, Aydin, Duygu2 (AUTHOR), Malkondu, Sait3 (AUTHOR), Erdemir, Serkan1 (AUTHOR)
Source: Food Chemistry. Apr2026:Part B, Vol. 508, pN.PAG-N.PAG. 1p.
Subjects: Thiophenol, Hydrazine, On-site evaluation, Food safety, Environmental sampling, Biological specimens, Fluorescent probes, Cell imaging
Abstract: Thiophenol (PhSH) and hydrazine (N₂H₄) are widely present in industrial, agricultural, and food-related processes, posing significant risks to human health and environmental safety. In this study, we introduce INS (2-(benzo[ d ]thiazol-2-yl)-4-((1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl 2,4-dinitrobenzenesulfonate), a dual-responsive fluorescent probe capable of selectively distinguishing PhSH and N₂H₄ through reaction-triggered modulation of d -PET, ICT, and ESIPT processes. INS displays rapid responses (≤2 min for PhSH and ≤ 5 min for N₂H₄), high sensitivity with detection limits of 0.731 and 1.016 μM, respectively, and excellent selectivity. Mechanistic investigations using NMR, TOF-MS, and DFT analyses confirmed the distinct sensing pathways. The probe demonstrated strong applicability in real matrices, enabling quantitative detection of both analytes in soil and water with recoveries of 98.9–112.2%. Portable paper strip, cotton swab, and smartphone-assisted imaging further supported its suitability for on-site testing. Additionally, food sample analyse and live-cell imaging confirmed the biocompatibility and practical utility of INS for monitoring hazardous contaminants. [Display omitted] • A novel dual-emission fluorescent probe INS was developed for PhSH and N₂H₄. • INS enables simultaneous and discriminative sensing on a single molecular scaffold. • Distinct d -PET, ICT, and ESIPT pathways afford selective dual fluorescence outputs. • The probe offers ultrafast response, low LODs, and strong anti-interference ability. • INS demonstrated applicability in real samples, paper sensors, and live-cell imaging. [ABSTRACT FROM AUTHOR]
Copyright of Food Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 192228562
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: A dual-channel smart fluorescent probe for rapid on-site detection of thiophenol and hydrazine in biological, environmental, and food samples.
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  Data: <searchLink fieldCode="AR" term="%22Oguz%2C+Mehmet%22">Oguz, Mehmet</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> m.oguz2011@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Aydin%2C+Duygu%22">Aydin, Duygu</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Malkondu%2C+Sait%22">Malkondu, Sait</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Erdemir%2C+Serkan%22">Erdemir, Serkan</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Food+Chemistry%22">Food Chemistry</searchLink>. Apr2026:Part B, Vol. 508, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Thiophenol%22">Thiophenol</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrazine%22">Hydrazine</searchLink><br /><searchLink fieldCode="DE" term="%22On-site+evaluation%22">On-site evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Food+safety%22">Food safety</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+sampling%22">Environmental sampling</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+specimens%22">Biological specimens</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescent+probes%22">Fluorescent probes</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+imaging%22">Cell imaging</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Thiophenol (PhSH) and hydrazine (N₂H₄) are widely present in industrial, agricultural, and food-related processes, posing significant risks to human health and environmental safety. In this study, we introduce INS (2-(benzo[ d ]thiazol-2-yl)-4-((1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl 2,4-dinitrobenzenesulfonate), a dual-responsive fluorescent probe capable of selectively distinguishing PhSH and N₂H₄ through reaction-triggered modulation of d -PET, ICT, and ESIPT processes. INS displays rapid responses (≤2 min for PhSH and ≤ 5 min for N₂H₄), high sensitivity with detection limits of 0.731 and 1.016 μM, respectively, and excellent selectivity. Mechanistic investigations using NMR, TOF-MS, and DFT analyses confirmed the distinct sensing pathways. The probe demonstrated strong applicability in real matrices, enabling quantitative detection of both analytes in soil and water with recoveries of 98.9–112.2%. Portable paper strip, cotton swab, and smartphone-assisted imaging further supported its suitability for on-site testing. Additionally, food sample analyse and live-cell imaging confirmed the biocompatibility and practical utility of INS for monitoring hazardous contaminants. [Display omitted] • A novel dual-emission fluorescent probe INS was developed for PhSH and N₂H₄. • INS enables simultaneous and discriminative sensing on a single molecular scaffold. • Distinct d -PET, ICT, and ESIPT pathways afford selective dual fluorescence outputs. • The probe offers ultrafast response, low LODs, and strong anti-interference ability. • INS demonstrated applicability in real samples, paper sensors, and live-cell imaging. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Food Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.foodchem.2026.148540
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Thiophenol
        Type: general
      – SubjectFull: Hydrazine
        Type: general
      – SubjectFull: On-site evaluation
        Type: general
      – SubjectFull: Food safety
        Type: general
      – SubjectFull: Environmental sampling
        Type: general
      – SubjectFull: Biological specimens
        Type: general
      – SubjectFull: Fluorescent probes
        Type: general
      – SubjectFull: Cell imaging
        Type: general
    Titles:
      – TitleFull: A dual-channel smart fluorescent probe for rapid on-site detection of thiophenol and hydrazine in biological, environmental, and food samples.
        Type: main
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            NameFull: Oguz, Mehmet
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            NameFull: Aydin, Duygu
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            NameFull: Malkondu, Sait
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            NameFull: Erdemir, Serkan
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            – D: 18
              M: 04
              Text: Apr2026:Part B
              Type: published
              Y: 2026
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              Value: 508
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