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Integration of hollow nanodices Ni(OH)2 and carbon nanotubes for exceptional noninvasive salivary glucose biosensor.

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Title:	Integration of hollow nanodices Ni(OH)2 and carbon nanotubes for exceptional noninvasive salivary glucose biosensor.
Authors:	Hsu, Li-Jen¹ (AUTHOR), Chang, Yu-Jr² (AUTHOR), Liao, Chen-Jie² (AUTHOR), Wang, Chi-Yuan² (AUTHOR), Gupta, Shivam¹ (AUTHOR), Lee, Chi-Young¹ (AUTHOR), Lai, Yi-Ting^1,2,3,4 (AUTHOR) laieating@mail.mcut.edu.tw, Tai, Nyan-Hwa^1,5 (AUTHOR) nhtai@mx.nthu.edu.tw
Source:	Journal of Alloys & Compounds. Apr2026, Vol. 1063, pN.PAG-N.PAG. 1p.
Subjects:	Glucose analysis, Carbon nanotubes, Treatment of diabetes, Blood sugar monitors, Nanostructured materials, Electrocatalysis, Electrodes, Blood sugar monitoring
Abstract:	The development of reliable, noninvasive glucose monitoring technologies is critical for effective diabetes management. In this work, we report a high-performance, nonenzymatic salivary glucose sensor based on hollow nanodice-shaped nickel hydroxide (NiND) integrating with acid-treated carbon nanotube (aCNT) on screen-printed electrodes (SPE). The NiND, inspired by Cu 2 O-templated strategy, exhibits an exceptional electrocatalytic activity due to its high surface area, amorphous structure, and abundant active sites. With the integration with the conductive aCNT layer,this unique hollow architecture enables the NiND/aCNT/SPE sensor achieves a high sensitivity of 1031.5 µA∙mM−1∙cm−2 over a glucose concentration range from 200 to 800 µM. In artificial saliva particularly, the electrodes demonstrate maintains excellent sensitivity of 1439.39 µA∙mM−1∙cm−2 over a 150–500 µM glucose concentration range, effectively distinguishing diabetic from healthy glucose levels. Besides, benefiting from the unique structural design, the NiND/aCNT/SPE features not only high long-term stability but also excellent specificity toward glucose against various interferences commonly existing in salivary, demonstrating the potential for practical noninvasive glucose biosensors in diabetic monitoring. [Display omitted] • Amorphous hollow Ni(OH)₂ nanodice synthesized for enzyme-free glucose sensing. • aCNT layer enhances conductivity and Ni(OH)₂ dispersion on SPE surface. • Optimized plasma and Nafion ratio improve adhesion and charge transfer. • High selectivity and 1439 μA mM⁻¹ cm⁻² sensitivity in artificial saliva. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	The development of reliable, noninvasive glucose monitoring technologies is critical for effective diabetes management. In this work, we report a high-performance, nonenzymatic salivary glucose sensor based on hollow nanodice-shaped nickel hydroxide (NiND) integrating with acid-treated carbon nanotube (aCNT) on screen-printed electrodes (SPE). The NiND, inspired by Cu 2 O-templated strategy, exhibits an exceptional electrocatalytic activity due to its high surface area, amorphous structure, and abundant active sites. With the integration with the conductive aCNT layer,this unique hollow architecture enables the NiND/aCNT/SPE sensor achieves a high sensitivity of 1031.5 µA∙mM−1∙cm−2 over a glucose concentration range from 200 to 800 µM. In artificial saliva particularly, the electrodes demonstrate maintains excellent sensitivity of 1439.39 µA∙mM−1∙cm−2 over a 150–500 µM glucose concentration range, effectively distinguishing diabetic from healthy glucose levels. Besides, benefiting from the unique structural design, the NiND/aCNT/SPE features not only high long-term stability but also excellent specificity toward glucose against various interferences commonly existing in salivary, demonstrating the potential for practical noninvasive glucose biosensors in diabetic monitoring. [Display omitted] • Amorphous hollow Ni(OH)₂ nanodice synthesized for enzyme-free glucose sensing. • aCNT layer enhances conductivity and Ni(OH)₂ dispersion on SPE surface. • Optimized plasma and Nafion ratio improve adhesion and charge transfer. • High selectivity and 1439 μA mM⁻¹ cm⁻² sensitivity in artificial saliva. [ABSTRACT FROM AUTHOR]
ISSN:	09258388
DOI:	10.1016/j.jallcom.2026.187755