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Integration of hollow nanodices Ni(OH)2 and carbon nanotubes for exceptional noninvasive salivary glucose biosensor.

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Title: Integration of hollow nanodices Ni(OH)2 and carbon nanotubes for exceptional noninvasive salivary glucose biosensor.
Authors: Hsu, Li-Jen1 (AUTHOR), Chang, Yu-Jr2 (AUTHOR), Liao, Chen-Jie2 (AUTHOR), Wang, Chi-Yuan2 (AUTHOR), Gupta, Shivam1 (AUTHOR), Lee, Chi-Young1 (AUTHOR), Lai, Yi-Ting1,2,3,4 (AUTHOR) laieating@mail.mcut.edu.tw, Tai, Nyan-Hwa1,5 (AUTHOR) nhtai@mx.nthu.edu.tw
Source: Journal of Alloys & Compounds. Apr2026, Vol. 1063, pN.PAG-N.PAG. 1p.
Subjects: Glucose analysis, Carbon nanotubes, Treatment of diabetes, Blood sugar monitors, Nanostructured materials, Electrocatalysis, Electrodes, Blood sugar monitoring
Abstract: The development of reliable, noninvasive glucose monitoring technologies is critical for effective diabetes management. In this work, we report a high-performance, nonenzymatic salivary glucose sensor based on hollow nanodice-shaped nickel hydroxide (NiND) integrating with acid-treated carbon nanotube (aCNT) on screen-printed electrodes (SPE). The NiND, inspired by Cu 2 O-templated strategy, exhibits an exceptional electrocatalytic activity due to its high surface area, amorphous structure, and abundant active sites. With the integration with the conductive aCNT layer,this unique hollow architecture enables the NiND/aCNT/SPE sensor achieves a high sensitivity of 1031.5 µA∙mM−1∙cm−2 over a glucose concentration range from 200 to 800 µM. In artificial saliva particularly, the electrodes demonstrate maintains excellent sensitivity of 1439.39 µA∙mM−1∙cm−2 over a 150–500 µM glucose concentration range, effectively distinguishing diabetic from healthy glucose levels. Besides, benefiting from the unique structural design, the NiND/aCNT/SPE features not only high long-term stability but also excellent specificity toward glucose against various interferences commonly existing in salivary, demonstrating the potential for practical noninvasive glucose biosensors in diabetic monitoring. [Display omitted] • Amorphous hollow Ni(OH)₂ nanodice synthesized for enzyme-free glucose sensing. • aCNT layer enhances conductivity and Ni(OH)₂ dispersion on SPE surface. • Optimized plasma and Nafion ratio improve adhesion and charge transfer. • High selectivity and 1439 μA mM⁻¹ cm⁻² sensitivity in artificial saliva. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Alloys & Compounds is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 192926141
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Integration of hollow nanodices Ni(OH)2 and carbon nanotubes for exceptional noninvasive salivary glucose biosensor.
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  Data: <searchLink fieldCode="AR" term="%22Hsu%2C+Li-Jen%22">Hsu, Li-Jen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Yu-Jr%22">Chang, Yu-Jr</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liao%2C+Chen-Jie%22">Liao, Chen-Jie</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Chi-Yuan%22">Wang, Chi-Yuan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gupta%2C+Shivam%22">Gupta, Shivam</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Chi-Young%22">Lee, Chi-Young</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lai%2C+Yi-Ting%22">Lai, Yi-Ting</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<i> laieating@mail.mcut.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Tai%2C+Nyan-Hwa%22">Tai, Nyan-Hwa</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<i> nhtai@mx.nthu.edu.tw</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Alloys+%26+Compounds%22">Journal of Alloys & Compounds</searchLink>. Apr2026, Vol. 1063, pN.PAG-N.PAG. 1p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Glucose+analysis%22">Glucose analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Carbon+nanotubes%22">Carbon nanotubes</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+diabetes%22">Treatment of diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sugar+monitors%22">Blood sugar monitors</searchLink><br /><searchLink fieldCode="DE" term="%22Nanostructured+materials%22">Nanostructured materials</searchLink><br /><searchLink fieldCode="DE" term="%22Electrocatalysis%22">Electrocatalysis</searchLink><br /><searchLink fieldCode="DE" term="%22Electrodes%22">Electrodes</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sugar+monitoring%22">Blood sugar monitoring</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The development of reliable, noninvasive glucose monitoring technologies is critical for effective diabetes management. In this work, we report a high-performance, nonenzymatic salivary glucose sensor based on hollow nanodice-shaped nickel hydroxide (NiND) integrating with acid-treated carbon nanotube (aCNT) on screen-printed electrodes (SPE). The NiND, inspired by Cu 2 O-templated strategy, exhibits an exceptional electrocatalytic activity due to its high surface area, amorphous structure, and abundant active sites. With the integration with the conductive aCNT layer,this unique hollow architecture enables the NiND/aCNT/SPE sensor achieves a high sensitivity of 1031.5 µA∙mM−1∙cm−2 over a glucose concentration range from 200 to 800 µM. In artificial saliva particularly, the electrodes demonstrate maintains excellent sensitivity of 1439.39 µA∙mM−1∙cm−2 over a 150–500 µM glucose concentration range, effectively distinguishing diabetic from healthy glucose levels. Besides, benefiting from the unique structural design, the NiND/aCNT/SPE features not only high long-term stability but also excellent specificity toward glucose against various interferences commonly existing in salivary, demonstrating the potential for practical noninvasive glucose biosensors in diabetic monitoring. [Display omitted] • Amorphous hollow Ni(OH)₂ nanodice synthesized for enzyme-free glucose sensing. • aCNT layer enhances conductivity and Ni(OH)₂ dispersion on SPE surface. • Optimized plasma and Nafion ratio improve adhesion and charge transfer. • High selectivity and 1439 μA mM⁻¹ cm⁻² sensitivity in artificial saliva. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Alloys & Compounds is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jallcom.2026.187755
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Glucose analysis
        Type: general
      – SubjectFull: Carbon nanotubes
        Type: general
      – SubjectFull: Treatment of diabetes
        Type: general
      – SubjectFull: Blood sugar monitors
        Type: general
      – SubjectFull: Nanostructured materials
        Type: general
      – SubjectFull: Electrocatalysis
        Type: general
      – SubjectFull: Electrodes
        Type: general
      – SubjectFull: Blood sugar monitoring
        Type: general
    Titles:
      – TitleFull: Integration of hollow nanodices Ni(OH)2 and carbon nanotubes for exceptional noninvasive salivary glucose biosensor.
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            NameFull: Hsu, Li-Jen
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            NameFull: Chang, Yu-Jr
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            NameFull: Liao, Chen-Jie
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            NameFull: Wang, Chi-Yuan
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            NameFull: Gupta, Shivam
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            NameFull: Lee, Chi-Young
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            NameFull: Lai, Yi-Ting
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            NameFull: Tai, Nyan-Hwa
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            – D: 15
              M: 04
              Text: Apr2026
              Type: published
              Y: 2026
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              Value: 1063
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            – TitleFull: Journal of Alloys & Compounds
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