Mn(II) Complex with Rutin—Spectral Characteristic, Quantum-Chemical Calculations, Antioxidant and α-Amylase Inhibitory Activity.
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| Title: | Mn(II) Complex with Rutin—Spectral Characteristic, Quantum-Chemical Calculations, Antioxidant and α-Amylase Inhibitory Activity. |
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| Authors: | Kozłowski, Maciej1 (AUTHOR) m.samsonowicz@pb.edu.pl, Kalinowska, Monika1,2 (AUTHOR) g.swiderski@pb.edu.pl, Samsonowicz, Mariola1 (AUTHOR), Świderski, Grzegorz1,2 (AUTHOR), Kalska-Szostko, Beata2 (AUTHOR) |
| Source: | Materials (1996-1944). Apr2026, Vol. 19 Issue 7, p1466. 22p. |
| Subjects: | Metal complexes, Rutin, Molecular models, Amylase inhibitors, Antioxidants, Spectrometry, Flavonoids, Pharmacology |
| Abstract: | Rutin is a naturally occurring flavonoid with well-documented antioxidant and pharmacological properties. In this study, a manganese(II) complex with rutin (Mn(II)-Rut) was synthesized in a solid state and characterized using FT-IR, Raman spectroscopy, thermogravimetric and elemental analysis, confirming its composition as C27H27O16Mn2·5H2O. The IR spectra indicated that rutin coordinates manganese ions through the carbonyl group at the C4 position and the hydroxyl group at the C5 atom, as well as the catecholic system. The antioxidant potential of both Mn(II)-Rut and rutin was evaluated using several spectrophotometric assays. The Mn(II)-Rut complex showed stronger activity in most spectrophotometric assays than rutin, i.e., in ABTS assay, 50.37 ± 2.64% vs. 41.49 ± 1.38%; in CUPRAC assay, 0.468 ± 0.006 mM Trolox vs. 0.379 ± 0.007 mM Trolox; and FRAP assay, 0.201 ± 0.002 µM vs. 0.189 ± 0.003 µM. However, the DPPH assay complex showed a diminished effect compared with ligand (IC50 2.78 ± 0.13 µM vs. 0.98 ± 0.04 µM for rutin). Quantum-chemical calculations were also performed using the Gaussian09 program to determine the optimized geometric structures, electron charge distribution, and the energies of the HOMOs and LUMOs in the analyzed molecules in order to discuss the antioxidant mechanism of the molecules. Enzymatic assays demonstrated that the Mn(II) complex with rutin exhibited a stronger α-amylase inhibitory effect compared to free rutin, which showed the potential antidiabetic activity of the compound. The results suggest that the Mn(II) complex of rutin possesses better antioxidant and α-amylase inhibitory activity than the ligand alone. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Rutin is a naturally occurring flavonoid with well-documented antioxidant and pharmacological properties. In this study, a manganese(II) complex with rutin (Mn(II)-Rut) was synthesized in a solid state and characterized using FT-IR, Raman spectroscopy, thermogravimetric and elemental analysis, confirming its composition as C27H27O16Mn2·5H2O. The IR spectra indicated that rutin coordinates manganese ions through the carbonyl group at the C4 position and the hydroxyl group at the C5 atom, as well as the catecholic system. The antioxidant potential of both Mn(II)-Rut and rutin was evaluated using several spectrophotometric assays. The Mn(II)-Rut complex showed stronger activity in most spectrophotometric assays than rutin, i.e., in ABTS assay, 50.37 ± 2.64% vs. 41.49 ± 1.38%; in CUPRAC assay, 0.468 ± 0.006 mM Trolox vs. 0.379 ± 0.007 mM Trolox; and FRAP assay, 0.201 ± 0.002 µM vs. 0.189 ± 0.003 µM. However, the DPPH assay complex showed a diminished effect compared with ligand (IC50 2.78 ± 0.13 µM vs. 0.98 ± 0.04 µM for rutin). Quantum-chemical calculations were also performed using the Gaussian09 program to determine the optimized geometric structures, electron charge distribution, and the energies of the HOMOs and LUMOs in the analyzed molecules in order to discuss the antioxidant mechanism of the molecules. Enzymatic assays demonstrated that the Mn(II) complex with rutin exhibited a stronger α-amylase inhibitory effect compared to free rutin, which showed the potential antidiabetic activity of the compound. The results suggest that the Mn(II) complex of rutin possesses better antioxidant and α-amylase inhibitory activity than the ligand alone. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 19961944 |
| DOI: | 10.3390/ma19071466 |
