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BSxCuBE‐Web – a web application for bioSAXS high‐throughput collection and experimental control.

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Title: BSxCuBE‐Web – a web application for bioSAXS high‐throughput collection and experimental control.
Authors: Florial, Jean Baptiste1,2 (AUTHOR), Oscarsson, Marcus2 (AUTHOR), Beteva, Antonia2 (AUTHOR), Fisher, Stuart2 (AUTHOR), Kieffer, Jérôme2 (AUTHOR), Calio, Antonino2 (AUTHOR), Fisher, Hayden2 (AUTHOR), Brennich, Martha1 (AUTHOR), Moussaoui, Dihia1 (AUTHOR), Popov, Anton1,2 (AUTHOR), Soler-Lopez, Montserrat2 (AUTHOR), Pernot, Petra2 (AUTHOR), Tully, Mark D.2 (AUTHOR) mark.tully@esrf.fr, McCarthy, Andrew A.1 (AUTHOR) andrewmc@embl.fr
Source: Journal of Synchrotron Radiation. May2026, Vol. 33 Issue 3, p884-895. 12p.
Subjects: Web-based user interfaces, Small-angle X-ray scattering, European Synchrotron Radiation Facility, System of systems, Acquisition of data, Synchrotrons
Abstract: The biological small‐angle X‐ray scattering (bioSAXS) beamline BM29 at the ESRF, operated by the ESRF–EMBL Joint Structural Biology and bioImaging Group (JSBIG), resumed user operation in September 2020 following the ESRF extremely brilliant source (EBS) upgrade. To exploit the high quality of X‐ray beam delivered by this new fourth‐generation synchrotron source, BM29 underwent significant refurbishment, including source optimization, instrument upgrades, and a complete redesign of the whole experimental control system. Here, we introduce the BioSAXS Customized Beamline Environment (BSxCuBE‐Web), a new open‐source, web‐based platform designed to streamline, automate and enhance bioSAXS data collection. BSxCuBE‐Web offers an intuitive and user‐friendly interface for expert and non‐expert users alike, to easily define and run bioSAXS experiments, as well as to monitor both raw and processed data. Its adaptable architecture facilitates its deployment on beamlines beyond the ESRF. In 2025 alone, BSxCuBE‐Web supported more than 97 experiments involving over 256 users at BM29. The interface has been successfully validated using a wide range of biological samples and continues to be actively developed in response to bioSAXS user feedback and evolving experimental requirements. User experience reports have been overwhelmingly positive, highlighting significant improvements in efficiency, accessibility, and reliability during data collection. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Synchrotron Radiation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: BSxCuBE‐Web – a web application for bioSAXS high‐throughput collection and experimental control.
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  Data: <searchLink fieldCode="AR" term="%22Florial%2C+Jean+Baptiste%22">Florial, Jean Baptiste</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oscarsson%2C+Marcus%22">Oscarsson, Marcus</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beteva%2C+Antonia%22">Beteva, Antonia</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fisher%2C+Stuart%22">Fisher, Stuart</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kieffer%2C+Jérôme%22">Kieffer, Jérôme</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Calio%2C+Antonino%22">Calio, Antonino</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fisher%2C+Hayden%22">Fisher, Hayden</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brennich%2C+Martha%22">Brennich, Martha</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moussaoui%2C+Dihia%22">Moussaoui, Dihia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Popov%2C+Anton%22">Popov, Anton</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soler-Lopez%2C+Montserrat%22">Soler-Lopez, Montserrat</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pernot%2C+Petra%22">Pernot, Petra</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tully%2C+Mark+D%2E%22">Tully, Mark D.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> mark.tully@esrf.fr</i><br /><searchLink fieldCode="AR" term="%22McCarthy%2C+Andrew+A%2E%22">McCarthy, Andrew A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> andrewmc@embl.fr</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Synchrotron+Radiation%22">Journal of Synchrotron Radiation</searchLink>. May2026, Vol. 33 Issue 3, p884-895. 12p.
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  Data: The biological small‐angle X‐ray scattering (bioSAXS) beamline BM29 at the ESRF, operated by the ESRF–EMBL Joint Structural Biology and bioImaging Group (JSBIG), resumed user operation in September 2020 following the ESRF extremely brilliant source (EBS) upgrade. To exploit the high quality of X‐ray beam delivered by this new fourth‐generation synchrotron source, BM29 underwent significant refurbishment, including source optimization, instrument upgrades, and a complete redesign of the whole experimental control system. Here, we introduce the BioSAXS Customized Beamline Environment (BSxCuBE‐Web), a new open‐source, web‐based platform designed to streamline, automate and enhance bioSAXS data collection. BSxCuBE‐Web offers an intuitive and user‐friendly interface for expert and non‐expert users alike, to easily define and run bioSAXS experiments, as well as to monitor both raw and processed data. Its adaptable architecture facilitates its deployment on beamlines beyond the ESRF. In 2025 alone, BSxCuBE‐Web supported more than 97 experiments involving over 256 users at BM29. The interface has been successfully validated using a wide range of biological samples and continues to be actively developed in response to bioSAXS user feedback and evolving experimental requirements. User experience reports have been overwhelmingly positive, highlighting significant improvements in efficiency, accessibility, and reliability during data collection. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Synchrotron Radiation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1107/S1600577526003528
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        Text: English
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      – SubjectFull: Web-based user interfaces
        Type: general
      – SubjectFull: Small-angle X-ray scattering
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      – SubjectFull: European Synchrotron Radiation Facility
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      – SubjectFull: System of systems
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              Text: May2026
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