Prussian Blue Nanoparticles Confined in Chitosan for In Vivo Cesium Ion Removal.
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| Title: | Prussian Blue Nanoparticles Confined in Chitosan for In Vivo Cesium Ion Removal. |
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| Authors: | Bordianu-Antochi, Irina E.1,2 (AUTHOR), Da Silva, Afitz2,3,4 (AUTHOR), Massasso, Giovanni1,3,5 (AUTHOR), Quignard, Françoise1,4 (AUTHOR), Stojanovic, Vanja3,5,6 (AUTHOR), Gary-Bobo, Magali3,6 (AUTHOR), Larionova, Joulia1 (AUTHOR), Guari, Yannick1,2 (AUTHOR) yannick.guari@umontpellier.fr |
| Source: | Nanomaterials (2079-4991). May2026, Vol. 16 Issue 9, p544. 14p. |
| Subjects: | Cesium ions, Nanoparticles, Decontamination (From gases, chemicals, etc.), Ion exchange resins, Chitosan, Pollution remediation, Nanocomposite materials |
| Abstract: | The development of efficient and biocompatible sorbent nanomaterials for cesium removal is critical for environmental and biomedical decontamination. Here, hybrid composites based on ultra-small Prussian blue or Zn Prussian blue-type nanoparticles confined within porous chitosan beads are proposed for Cs+ extraction. Nanoparticle confinement ensures homogeneous dispersion and improved accessibility of ion-exchange sites, while preserving the porous polymeric network, as confirmed by physicochemical characterization. Cs+ adsorption was investigated under neutral and acidic conditions (pH 7.2 and 1.2), at concentrations of 0–9 mmol/L and contact times of 0–50 h, showing efficient uptake and favorable kinetics, with confirmed stability in simulated gastric fluid. In vivo performance was assessed in a mouse model of cesium contamination (70 mg Cs+/kg). Treatment with nanocomposites (225 mg/kg) was compared to bulk Prussian blue (75 mg/kg), revealing enhanced detoxification efficiency. Histological analysis of liver, spleen, and kidney tissues showed no detectable structural damage, consistent with unchanged systemic biomarkers. Overall, the proposed chitosan-confined Prussian blue-type nanocomposites combine high Cs+ removal efficiency, kinetic accessibility, and in vivo safety, highlighting their potential for decorporation applications. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | The development of efficient and biocompatible sorbent nanomaterials for cesium removal is critical for environmental and biomedical decontamination. Here, hybrid composites based on ultra-small Prussian blue or Zn Prussian blue-type nanoparticles confined within porous chitosan beads are proposed for Cs+ extraction. Nanoparticle confinement ensures homogeneous dispersion and improved accessibility of ion-exchange sites, while preserving the porous polymeric network, as confirmed by physicochemical characterization. Cs+ adsorption was investigated under neutral and acidic conditions (pH 7.2 and 1.2), at concentrations of 0–9 mmol/L and contact times of 0–50 h, showing efficient uptake and favorable kinetics, with confirmed stability in simulated gastric fluid. In vivo performance was assessed in a mouse model of cesium contamination (70 mg Cs+/kg). Treatment with nanocomposites (225 mg/kg) was compared to bulk Prussian blue (75 mg/kg), revealing enhanced detoxification efficiency. Histological analysis of liver, spleen, and kidney tissues showed no detectable structural damage, consistent with unchanged systemic biomarkers. Overall, the proposed chitosan-confined Prussian blue-type nanocomposites combine high Cs+ removal efficiency, kinetic accessibility, and in vivo safety, highlighting their potential for decorporation applications. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 20794991 |
| DOI: | 10.3390/nano16090544 |
