A novel titanium-Schiff base complex for targeting triple negative breast cancer: synthesis, characterisation, and apoptosis induction.
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| Title: | A novel titanium-Schiff base complex for targeting triple negative breast cancer: synthesis, characterisation, and apoptosis induction. |
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| Authors: | Chethana, M. H.1 (AUTHOR), Priyadarshini, A.N.2,3 (AUTHOR), Sudhanva, M.S.2,3 (AUTHOR), Rangappa, Shobith2,3 (AUTHOR), Mallu, P.1 (AUTHOR) pmallu@jssstuniv.in |
| Source: | Materials Research Innovations. Jun2026, Vol. 30 Issue 4, p410-419. 10p. |
| Subjects: | Triple-negative breast cancer, Metal complexes, Titanium, Antineoplastic agents, Thermal stability, Apoptosis, Schiff bases, Molecular docking |
| Abstract: | Breast cancer is the most prevalent cancer among women globally, highlighting the need for alternative metal-based therapies. In the present work, dopamine-derived Schiff base Ti(IV) complex was synthesized and characterized to assess its structural, thermal, and biological attributes. Spectroscopic studies confirmed the existence of a six-coordinated titanium complex, while thermogravimetric analysis indicated significant thermal stability with TiO₂ formation above 600 °C. The complex demonstrated significant in vitro anticancer efficacy against the MDA-MB-231 cell line, with IC₅₀ values between 60–80 µM, showing enhanced sensitivity relative to HeLa cells. Fluorescence staining with Hoechst and propidium iodide revealed apoptosis-related nuclear and membrane changes. Molecular docking studies corroborated the experimental data, indicating robust binding interactions with a binding energy of −9.69 kcal/mol. These findings underscore the potential of dopamine-based Ti(IV) complexes as promising candidates for anticancer therapies. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Breast cancer is the most prevalent cancer among women globally, highlighting the need for alternative metal-based therapies. In the present work, dopamine-derived Schiff base Ti(IV) complex was synthesized and characterized to assess its structural, thermal, and biological attributes. Spectroscopic studies confirmed the existence of a six-coordinated titanium complex, while thermogravimetric analysis indicated significant thermal stability with TiO₂ formation above 600 °C. The complex demonstrated significant in vitro anticancer efficacy against the MDA-MB-231 cell line, with IC₅₀ values between 60–80 µM, showing enhanced sensitivity relative to HeLa cells. Fluorescence staining with Hoechst and propidium iodide revealed apoptosis-related nuclear and membrane changes. Molecular docking studies corroborated the experimental data, indicating robust binding interactions with a binding energy of −9.69 kcal/mol. These findings underscore the potential of dopamine-based Ti(IV) complexes as promising candidates for anticancer therapies. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 14328917 |
| DOI: | 10.1080/14328917.2025.2604696 |
