A Fuzzy Model of Glucose Regulation.

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Bibliographic Details
Title: A Fuzzy Model of Glucose Regulation.
Authors: Ward, Em1, Martin, Terry2 tmartin@uark.edu
Source: Journal of Medical Systems. Jun2006, Vol. 30 Issue 3, p187-203. 17p. 2 Diagrams, 2 Charts, 10 Graphs.
Subjects: Glucose, Fuzzy logic, Diabetes, Diagnosis of diabetes, Treatment of diabetes, Cell receptors, People with diabetes, Insulin, Hormones
Abstract: We present a detailed glucose regulation model using fuzzy inference system (FIS) descriptions of hormonal control action and the familiar Michaelis–Menten (M–M) kinetic description for glucose transport. The fuzzy M–M model is compared and contrasted with a well-known comprehensive glucose model. The two models give similar results for glucose response, endogenous glucose production, and total uptake. The fuzzy M–M model features a renal subsystem that provides 25% of the endogenous glucose production. The work demonstrates the successful application of fuzzy logic and fuzzy inference to biological modelling. The flexibility of fuzzy inference, a linguistic description technique, permits conceptually simple statements about nonlinear processes. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:We present a detailed glucose regulation model using fuzzy inference system (FIS) descriptions of hormonal control action and the familiar Michaelis–Menten (M–M) kinetic description for glucose transport. The fuzzy M–M model is compared and contrasted with a well-known comprehensive glucose model. The two models give similar results for glucose response, endogenous glucose production, and total uptake. The fuzzy M–M model features a renal subsystem that provides 25% of the endogenous glucose production. The work demonstrates the successful application of fuzzy logic and fuzzy inference to biological modelling. The flexibility of fuzzy inference, a linguistic description technique, permits conceptually simple statements about nonlinear processes. [ABSTRACT FROM AUTHOR]
ISSN:01485598
DOI:10.1007/s10916-005-7983-2