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Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension

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Title:	Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension
Authors:	Park, Hyohun¹, Hasegawa, Goji² goji@koto.kpu-m.ac.jp, Obayashi, Hiroshi³, Fujinami, Aya⁴, Ohta, Mitsuhiro⁴, Hara, Hirokazu⁵, Adachi, Tetsuo⁵, Tamaki, Shoko¹, Nakajima, Yoshiki¹, Kimura, Fumiaki¹, Ogata, Masakazu², Fukui, Michiaki², Yoshikawa, Toshikazu², Nakamura, Naoto²
Source:	Clinica Chimica Acta. Dec2006, Vol. 374 Issue 1/2, p129-134. 6p.
Subjects:	Diabetes complications, Pancreatic secretions, Insulin resistance, Blood circulation disorders
Abstract:	Abstract: Background: It is now well established that vascular inflammation and endothelial dysfunction associated with cardiovascular diseases contributes to insulin resistance. Methods: We investigated the relationship between the homeostasis model assessment-insulin resistance index (HOMA-R) and various serum inflammatory markers and the effect of losartan on serum concentrations of these markers in patients with type 2 diabetes and hypertension. The patients were divided into 2 groups according to the value of HOMA-R with 60 patients with values=2.4 in Group A and 44 patients with values>2.5 in Group B. The variables were measured at baseline and after 6 months of treatment with losartan (50 mg/day). Results: The HOMA-R concentrations were positively related to TNF-α (r =0.336, P <0.01) and inversely related to adiponectin (r =−0.405, P <0.01) and extracellular-superoxide dismutase (EC-SOD) (r =−0.452, P <0.01). Stepwise multiple regression analysis showed a significant relationship between HOMA-R and adiponectin (F =8.74) and EC-SOD (F =14.39). In Group B, losartan treatment significantly increased the serum concentrations of EC-SOD and adiponectin and decreased TNF-α and HOMA-R. Conclusion: Serum EC-SOD concentrations may be a sensitive biochemical marker of insulin resistance in patients with type 2 diabetes and hypertension and that losartan improves insulin sensitivity by increasing EC-SOD and adiponectin production and decreasing TNF-α production. [Copyright &y& Elsevier]
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Database:	Engineering Source

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Abstract:	Abstract: Background: It is now well established that vascular inflammation and endothelial dysfunction associated with cardiovascular diseases contributes to insulin resistance. Methods: We investigated the relationship between the homeostasis model assessment-insulin resistance index (HOMA-R) and various serum inflammatory markers and the effect of losartan on serum concentrations of these markers in patients with type 2 diabetes and hypertension. The patients were divided into 2 groups according to the value of HOMA-R with 60 patients with values=2.4 in Group A and 44 patients with values>2.5 in Group B. The variables were measured at baseline and after 6 months of treatment with losartan (50 mg/day). Results: The HOMA-R concentrations were positively related to TNF-α (r =0.336, P <0.01) and inversely related to adiponectin (r =−0.405, P <0.01) and extracellular-superoxide dismutase (EC-SOD) (r =−0.452, P <0.01). Stepwise multiple regression analysis showed a significant relationship between HOMA-R and adiponectin (F =8.74) and EC-SOD (F =14.39). In Group B, losartan treatment significantly increased the serum concentrations of EC-SOD and adiponectin and decreased TNF-α and HOMA-R. Conclusion: Serum EC-SOD concentrations may be a sensitive biochemical marker of insulin resistance in patients with type 2 diabetes and hypertension and that losartan improves insulin sensitivity by increasing EC-SOD and adiponectin production and decreasing TNF-α production. [Copyright &y& Elsevier]
ISSN:	00098981
DOI:	10.1016/j.cca.2006.06.004