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Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension

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Title: Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension
Authors: Park, Hyohun1, Hasegawa, Goji2 goji@koto.kpu-m.ac.jp, Obayashi, Hiroshi3, Fujinami, Aya4, Ohta, Mitsuhiro4, Hara, Hirokazu5, Adachi, Tetsuo5, Tamaki, Shoko1, Nakajima, Yoshiki1, Kimura, Fumiaki1, Ogata, Masakazu2, Fukui, Michiaki2, Yoshikawa, Toshikazu2, Nakamura, Naoto2
Source: Clinica Chimica Acta. Dec2006, Vol. 374 Issue 1/2, p129-134. 6p.
Subjects: Diabetes complications, Pancreatic secretions, Insulin resistance, Blood circulation disorders
Abstract: Abstract: Background: It is now well established that vascular inflammation and endothelial dysfunction associated with cardiovascular diseases contributes to insulin resistance. Methods: We investigated the relationship between the homeostasis model assessment-insulin resistance index (HOMA-R) and various serum inflammatory markers and the effect of losartan on serum concentrations of these markers in patients with type 2 diabetes and hypertension. The patients were divided into 2 groups according to the value of HOMA-R with 60 patients with values=2.4 in Group A and 44 patients with values>2.5 in Group B. The variables were measured at baseline and after 6 months of treatment with losartan (50 mg/day). Results: The HOMA-R concentrations were positively related to TNF-α (r =0.336, P <0.01) and inversely related to adiponectin (r =−0.405, P <0.01) and extracellular-superoxide dismutase (EC-SOD) (r =−0.452, P <0.01). Stepwise multiple regression analysis showed a significant relationship between HOMA-R and adiponectin (F =8.74) and EC-SOD (F =14.39). In Group B, losartan treatment significantly increased the serum concentrations of EC-SOD and adiponectin and decreased TNF-α and HOMA-R. Conclusion: Serum EC-SOD concentrations may be a sensitive biochemical marker of insulin resistance in patients with type 2 diabetes and hypertension and that losartan improves insulin sensitivity by increasing EC-SOD and adiponectin production and decreasing TNF-α production. [Copyright &y& Elsevier]
Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Park%2C+Hyohun%22&quot;&gt;Park, Hyohun&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hasegawa%2C+Goji%22&quot;&gt;Hasegawa, Goji&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;i&gt; goji@koto.kpu-m.ac.jp&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Obayashi%2C+Hiroshi%22&quot;&gt;Obayashi, Hiroshi&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fujinami%2C+Aya%22&quot;&gt;Fujinami, Aya&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ohta%2C+Mitsuhiro%22&quot;&gt;Ohta, Mitsuhiro&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hara%2C+Hirokazu%22&quot;&gt;Hara, Hirokazu&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Adachi%2C+Tetsuo%22&quot;&gt;Adachi, Tetsuo&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tamaki%2C+Shoko%22&quot;&gt;Tamaki, Shoko&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nakajima%2C+Yoshiki%22&quot;&gt;Nakajima, Yoshiki&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kimura%2C+Fumiaki%22&quot;&gt;Kimura, Fumiaki&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ogata%2C+Masakazu%22&quot;&gt;Ogata, Masakazu&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fukui%2C+Michiaki%22&quot;&gt;Fukui, Michiaki&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yoshikawa%2C+Toshikazu%22&quot;&gt;Yoshikawa, Toshikazu&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nakamura%2C+Naoto%22&quot;&gt;Nakamura, Naoto&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Clinica+Chimica+Acta%22&quot;&gt;Clinica Chimica Acta&lt;/searchLink&gt;. Dec2006, Vol. 374 Issue 1/2, p129-134. 6p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diabetes+complications%22&quot;&gt;Diabetes complications&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pancreatic+secretions%22&quot;&gt;Pancreatic secretions&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Insulin+resistance%22&quot;&gt;Insulin resistance&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Blood+circulation+disorders%22&quot;&gt;Blood circulation disorders&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Background: It is now well established that vascular inflammation and endothelial dysfunction associated with cardiovascular diseases contributes to insulin resistance. Methods: We investigated the relationship between the homeostasis model assessment-insulin resistance index (HOMA-R) and various serum inflammatory markers and the effect of losartan on serum concentrations of these markers in patients with type 2 diabetes and hypertension. The patients were divided into 2 groups according to the value of HOMA-R with 60 patients with values=2.4 in Group A and 44 patients with values&gt;2.5 in Group B. The variables were measured at baseline and after 6&#160;months of treatment with losartan (50&#160;mg/day). Results: The HOMA-R concentrations were positively related to TNF-α (r =0.336, P &lt;0.01) and inversely related to adiponectin (r =−0.405, P &lt;0.01) and extracellular-superoxide dismutase (EC-SOD) (r =−0.452, P &lt;0.01). Stepwise multiple regression analysis showed a significant relationship between HOMA-R and adiponectin (F =8.74) and EC-SOD (F =14.39). In Group B, losartan treatment significantly increased the serum concentrations of EC-SOD and adiponectin and decreased TNF-α and HOMA-R. Conclusion: Serum EC-SOD concentrations may be a sensitive biochemical marker of insulin resistance in patients with type 2 diabetes and hypertension and that losartan improves insulin sensitivity by increasing EC-SOD and adiponectin production and decreasing TNF-α production. [Copyright &amp;y&amp; Elsevier]
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  Data: &lt;i&gt;Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.cca.2006.06.004
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        Text: English
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        PageCount: 6
        StartPage: 129
    Subjects:
      – SubjectFull: Diabetes complications
        Type: general
      – SubjectFull: Pancreatic secretions
        Type: general
      – SubjectFull: Insulin resistance
        Type: general
      – SubjectFull: Blood circulation disorders
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      – TitleFull: Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension
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              Text: Dec2006
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