View in EDS

Factors affecting release rate of diltiazem hydrochloride from poly (2-hydroxyethyl methacrylate) matrices

Saved in:
Bibliographic Details
Title: Factors affecting release rate of diltiazem hydrochloride from poly (2-hydroxyethyl methacrylate) matrices
Authors: Yanagawa, F.1 fumikiyanagawa@gmail.com, Ishii, Y.2, Onuki, Y.1, Morishita, M.1, Takayama, K.1
Source: Colloids & Surfaces B: Biointerfaces. May2008, Vol. 63 Issue 1, p146-152. 7p.
Subjects: Drugs, Therapeutics, Hypertension, Photopolymerization
Abstract: Abstract: Sustained release diltiazem hydrochloride (DIL) formulation is widely used over 110 countries worldwide, and is among the drugs recommended as a first-line therapy in the major guidelines for the management of hypertension. In search for a most suitable controlled release formulation of DIL, we investigated poly (2-hydroxyethyl methacrylate) matrix (pHEMA matrix) synthesized by photopolymerization. Factors affecting the release rate of DIL from pHEMA matrices were investigated, focusing on the internal structure of the matrices. The effects of the porosity (ɛ), the fractal dimensions (D f) and the microscopic viscosity (η matrix) of the matrices on the release rate of DIL were investigated on the basis of the linear least square equation as well as the Higuchi''s equation. A relation between the actual value and predicted value based on the linear least square equation exhibited a fairly good linearity (r =0.979). Furthermore, the release rate of DIL was represented based on the Higuchi''s equation including the values of ɛ, D f and η matrix. It is likely that the release rate of DIL from pHEMA matrices is mainly controlled by ɛ and D f, but η matrix was less effective. [Copyright &y& Elsevier]
Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 31400356
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Factors affecting release rate of diltiazem hydrochloride from poly (2-hydroxyethyl methacrylate) matrices
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Yanagawa%2C+F%2E%22">Yanagawa, F.</searchLink><relatesTo>1</relatesTo><i> fumikiyanagawa@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Ishii%2C+Y%2E%22">Ishii, Y.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Onuki%2C+Y%2E%22">Onuki, Y.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Morishita%2C+M%2E%22">Morishita, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Takayama%2C+K%2E%22">Takayama, K.</searchLink><relatesTo>1</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+B%3A+Biointerfaces%22">Colloids & Surfaces B: Biointerfaces</searchLink>. May2008, Vol. 63 Issue 1, p146-152. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Hypertension%22">Hypertension</searchLink><br /><searchLink fieldCode="DE" term="%22Photopolymerization%22">Photopolymerization</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Sustained release diltiazem hydrochloride (DIL) formulation is widely used over 110 countries worldwide, and is among the drugs recommended as a first-line therapy in the major guidelines for the management of hypertension. In search for a most suitable controlled release formulation of DIL, we investigated poly (2-hydroxyethyl methacrylate) matrix (pHEMA matrix) synthesized by photopolymerization. Factors affecting the release rate of DIL from pHEMA matrices were investigated, focusing on the internal structure of the matrices. The effects of the porosity (ɛ), the fractal dimensions (D f) and the microscopic viscosity (η matrix) of the matrices on the release rate of DIL were investigated on the basis of the linear least square equation as well as the Higuchi''s equation. A relation between the actual value and predicted value based on the linear least square equation exhibited a fairly good linearity (r =0.979). Furthermore, the release rate of DIL was represented based on the Higuchi''s equation including the values of ɛ, D f and η matrix. It is likely that the release rate of DIL from pHEMA matrices is mainly controlled by ɛ and D f, but η matrix was less effective. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=31400356
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.colsurfb.2007.11.020
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 146
    Subjects:
      – SubjectFull: Drugs
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Hypertension
        Type: general
      – SubjectFull: Photopolymerization
        Type: general
    Titles:
      – TitleFull: Factors affecting release rate of diltiazem hydrochloride from poly (2-hydroxyethyl methacrylate) matrices
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yanagawa, F.
      – PersonEntity:
          Name:
            NameFull: Ishii, Y.
      – PersonEntity:
          Name:
            NameFull: Onuki, Y.
      – PersonEntity:
          Name:
            NameFull: Morishita, M.
      – PersonEntity:
          Name:
            NameFull: Takayama, K.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2008
              Type: published
              Y: 2008
          Identifiers:
            – Type: issn-print
              Value: 09277765
          Numbering:
            – Type: volume
              Value: 63
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Colloids & Surfaces B: Biointerfaces
              Type: main
ResultId 1