View in EDS

3-mercaptopropylphosphonic acid modified gold electrode for electrochemical detection of dopamine

Saved in:
Bibliographic Details
Title: 3-mercaptopropylphosphonic acid modified gold electrode for electrochemical detection of dopamine
Authors: Chen, Yu1, Guo, Li-Rong1, Chen, Wei2, Yang, Xiao-Jing1, Jin, Bo2, Zheng, Li-Min1 lmzheng@nju.edu.cn, Xia, Xing-Hua2 xhxia@nju.edu.cn
Source: Bioelectrochemistry. Apr2009, Vol. 75 Issue 1, p26-31. 6p.
Subjects: Dopamine, Bromocriptine, Phosphonic acids, Phosphonates
Abstract: Abstract: It is reported for the first time that the phosphonic acid terminated self-assembled layers assembled on a gold surface could be used as a functional interface to sensitively and selectively detect dopamine (DA) in the presence of highly concentrated ascorbic acid (AA). X-ray photoelectron spectroscopic (XPS) and reductive desorption measurements proved that the 3-mercaptopropylphosphonic acid [HS-(CH2)3-PO3H2, MPPA] was successfully immobilized on the gold surface via S–Au bond. Making use of the electrostatic interactions between the negatively charged phosphonic acid groups on the electrode surface and DA and AA, the MPPA modified electrode was successfully used to electrochemically discriminate between DA and AA. Cyclic voltammetry measurements shown that the MPPA modified electrodes almost completely inhibited the electrochemical reaction of AA. Therefore, DA can be selectively and sensitively determined by using the differential pulse voltammetry technique although high concentration of AA is present. [Copyright &y& Elsevier]
Copyright of Bioelectrochemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:Abstract: It is reported for the first time that the phosphonic acid terminated self-assembled layers assembled on a gold surface could be used as a functional interface to sensitively and selectively detect dopamine (DA) in the presence of highly concentrated ascorbic acid (AA). X-ray photoelectron spectroscopic (XPS) and reductive desorption measurements proved that the 3-mercaptopropylphosphonic acid [HS-(CH2)3-PO3H2, MPPA] was successfully immobilized on the gold surface via S–Au bond. Making use of the electrostatic interactions between the negatively charged phosphonic acid groups on the electrode surface and DA and AA, the MPPA modified electrode was successfully used to electrochemically discriminate between DA and AA. Cyclic voltammetry measurements shown that the MPPA modified electrodes almost completely inhibited the electrochemical reaction of AA. Therefore, DA can be selectively and sensitively determined by using the differential pulse voltammetry technique although high concentration of AA is present. [Copyright &y& Elsevier]
ISSN:15675394
DOI:10.1016/j.bioelechem.2008.12.005