Bibliographic Details
| Title: |
Tailoring carboxymethyl guargum hydrogel with nanosilica for sustained transdermal release of diclofenac sodium |
| Authors: |
Giri, Arindam1, Ghosh, Totan2, Panda, Asit Baran3, Pal, Sagar4, Bandyopdhyay, Abhijit1 abhijitbandyopadhyay@yahoo.co.in |
| Source: |
Carbohydrate Polymers. Jan2012, Vol. 87 Issue 2, p1532-1538. 7p. |
| Subjects: |
Carboxymethyl compounds, Polymer colloids, Nanocomposite materials, Silica, Guar gum, Diclofenac, Sodium |
| Abstract: |
Abstract: Carboxymethyl guar gum (CMG) was structurally tailored with aqueous-nanosilica sol for controlled transdermal release of diclofenac sodium. Nanosilica was administered in low to moderately high concentration range to synthesize various, novel CMG–silica hybrid nanocomposites. Spectroscopy together with thermogravimetry, morphology, swelling and rheological studies proved that 1wt% nanosilica content was the best physical formulation. The drug release studies from different hydrogel nanocomposites exhibited slower release than neat CMG. 1wt% nanosilica loaded hydrogel nanocomposite gave slowest but steady release profile among all other nanocomposites due to its highly viscous nature owing to most compact microstructure. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
