Bibliographic Details
| Title: |
The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour |
| Authors: |
Top, S.1, Kaloun, E.B.1, Vessières, A.1, Laıos, I.2, Leclercq, G.2, Jaouen, G.1 jaouen@ext.jussieu.fr |
| Source: |
Journal of Organometallic Chemistry. Feb2002, Vol. 643/644, p350. 7p. |
| Subjects: |
Tamoxifen, Antineoplastic agents, Ligand exchange chromatography |
| Abstract: |
The synthesis of 4′, a titanocene derivative of the anticancer drug tamoxifen is presented together with its biochemical properties. Compound 4′ is prepared by a McMurry coupling followed by a ligand exchange. Compound 4′ reveals an unexpected proliferative effect on the hormone-dependent cell line MCF7. Surprisingly this effect is also observed with Cp2TiCl2 alone. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
