The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour
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| Title: | The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour |
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| Authors: | Top, S.1, Kaloun, E.B.1, Vessières, A.1, Laıos, I.2, Leclercq, G.2, Jaouen, G.1 jaouen@ext.jussieu.fr |
| Source: | Journal of Organometallic Chemistry. Feb2002, Vol. 643/644, p350. 7p. |
| Subjects: | Tamoxifen, Antineoplastic agents, Ligand exchange chromatography |
| Abstract: | The synthesis of 4′, a titanocene derivative of the anticancer drug tamoxifen is presented together with its biochemical properties. Compound 4′ is prepared by a McMurry coupling followed by a ligand exchange. Compound 4′ reveals an unexpected proliferative effect on the hormone-dependent cell line MCF7. Surprisingly this effect is also observed with Cp2TiCl2 alone. [Copyright &y& Elsevier] |
| Copyright of Journal of Organometallic Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 7759209 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S0022-328X(01)01271-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 350 Subjects: – SubjectFull: Tamoxifen Type: general – SubjectFull: Antineoplastic agents Type: general – SubjectFull: Ligand exchange chromatography Type: general Titles: – TitleFull: The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Top, S. – PersonEntity: Name: NameFull: Kaloun, E.B. – PersonEntity: Name: NameFull: Vessières, A. – PersonEntity: Name: NameFull: Laıos, I. – PersonEntity: Name: NameFull: Leclercq, G. – PersonEntity: Name: NameFull: Jaouen, G. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 0022328X Numbering: – Type: volume Value: 643/644 Titles: – TitleFull: Journal of Organometallic Chemistry Type: main |
| ResultId | 1 |
