Bibliographic Details
| Title: |
BRCT domains: A little more than kin, and less than kind |
| Authors: |
Gerloff, Dietlind L.1, Woods, Nicholas T.2, Farago, April A.1, Monteiro, Alvaro N.A.2 alvaro.monteiro@moffitt.org |
| Source: |
FEBS Letters. Aug2012, Vol. 586 Issue 17, p2711-2716. 6p. |
| Subjects: |
Protein structure, C-terminal binding proteins, DNA damage, Forkhead transcription factors, Genomes, Phosphorylation, Cellular signal transduction |
| Abstract: |
Abstract: BRCT domains are versatile protein modular domains found as single units or as multiple copies in more than 20 different proteins in the human genome. Interestingly, most BRCT-containing proteins function in the same biological process, the DNA damage response network, but show specificity in their molecular interactions. BRCT domains have been found to bind a wide array of ligands from proteins, phosphorylated linear motifs, and DNA. Here we discuss the biology of BRCT domains and how a domain-centric analysis can aid in the understanding of signal transduction events in the DNA damage response network. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
