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Prolongation of TCD-enhanced Doppler signal by continuous infusion of levovist

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Title: Prolongation of TCD-enhanced Doppler signal by continuous infusion of levovist
Authors: Totaro, Rocco1 totaro@cc.univaq.it, Baldassarre, Massimo1, Sacco, Simona1, Marini, Carmine1, Carolei, Antonio1
Source: Ultrasound in Medicine & Biology. Nov2002, Vol. 28 Issue 11/12, p1555. 5p.
Subjects: Contrast media, Transcranial Doppler ultrasonography, Cerebral arteries
Abstract: This study evaluated the effects of two different rates of infusion of echo-contrast agents (ECA) on signal enhancement. A total of 15 patients with insufficient Doppler signal due to inadequate transtemporal acoustic bone window were examined. Signal from the middle cerebral artery was recorded during the IV infusion of Levovist® (300 mg/mL). Increment of signal enhancement in dB, time to signal enhancement appearance, time to clinically useful signal enhancement appearance, and duration of clinically useful signal enhancement were assessed during two infusions at the rate of 1 and 0.66 mL/min, respectively. Increment of signal enhancement was similar at the rate of 1 and 0.66 mL/min (p = 0.4). Mean time to signal enhancement appearance and mean time to clinically useful signal enhancement appearance were not significantly different with the two rates of infusion (p = 0.9 and p = 0.3, respectively). Mean duration of clinically useful signal enhancement was significantly higher with the infusion rate of 0.66 mL/min as compared to 1 mL/min (p < 0.0001). Levovist® injected at the infusion rate of 0.66 mL/min prolonged the mean duration of signal enhancement, maintaining its effectiveness. (E-mail: totaro@cc.univaq.it) [Copyright &y& Elsevier]
Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 8724918
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Prolongation of TCD-enhanced Doppler signal by continuous infusion of levovist
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Totaro%2C+Rocco%22&quot;&gt;Totaro, Rocco&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; totaro@cc.univaq.it&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Baldassarre%2C+Massimo%22&quot;&gt;Baldassarre, Massimo&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sacco%2C+Simona%22&quot;&gt;Sacco, Simona&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Marini%2C+Carmine%22&quot;&gt;Marini, Carmine&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Carolei%2C+Antonio%22&quot;&gt;Carolei, Antonio&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Ultrasound+in+Medicine+%26+Biology%22&quot;&gt;Ultrasound in Medicine &amp; Biology&lt;/searchLink&gt;. Nov2002, Vol. 28 Issue 11/12, p1555. 5p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Contrast+media%22&quot;&gt;Contrast media&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Transcranial+Doppler+ultrasonography%22&quot;&gt;Transcranial Doppler ultrasonography&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cerebral+arteries%22&quot;&gt;Cerebral arteries&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study evaluated the effects of two different rates of infusion of echo-contrast agents (ECA) on signal enhancement. A total of 15 patients with insufficient Doppler signal due to inadequate transtemporal acoustic bone window were examined. Signal from the middle cerebral artery was recorded during the IV infusion of Levovist&#174; (300 mg/mL). Increment of signal enhancement in dB, time to signal enhancement appearance, time to clinically useful signal enhancement appearance, and duration of clinically useful signal enhancement were assessed during two infusions at the rate of 1 and 0.66 mL/min, respectively. Increment of signal enhancement was similar at the rate of 1 and 0.66 mL/min (p = 0.4). Mean time to signal enhancement appearance and mean time to clinically useful signal enhancement appearance were not significantly different with the two rates of infusion (p = 0.9 and p = 0.3, respectively). Mean duration of clinically useful signal enhancement was significantly higher with the infusion rate of 0.66 mL/min as compared to 1 mL/min (p &lt; 0.0001). Levovist&#174; injected at the infusion rate of 0.66 mL/min prolonged the mean duration of signal enhancement, maintaining its effectiveness. (E-mail: totaro@cc.univaq.it) [Copyright &amp;y&amp; Elsevier]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Ultrasound in Medicine &amp; Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/S0301-5629(02)00607-5
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 1555
    Subjects:
      – SubjectFull: Contrast media
        Type: general
      – SubjectFull: Transcranial Doppler ultrasonography
        Type: general
      – SubjectFull: Cerebral arteries
        Type: general
    Titles:
      – TitleFull: Prolongation of TCD-enhanced Doppler signal by continuous infusion of levovist
        Type: main
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            NameFull: Totaro, Rocco
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            NameFull: Baldassarre, Massimo
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            NameFull: Sacco, Simona
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            NameFull: Marini, Carmine
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            NameFull: Carolei, Antonio
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          Dates:
            – D: 01
              M: 11
              Text: Nov2002
              Type: published
              Y: 2002
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              Value: 28
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              Value: 11/12
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            – TitleFull: Ultrasound in Medicine & Biology
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