View in EDS PDF Full Text

F-FDG uptake in breast cancer correlates with immunohistochemically defined subtypes.

Saved in:
Bibliographic Details
Title: F-FDG uptake in breast cancer correlates with immunohistochemically defined subtypes.
Authors: Koo, Hye, Park, Jeong1, Kang, Keon2, Cho, Nariya3, Chang, Jung3, Bae, Min3, Kim, Won3, Lee, Su3, Kim, Mi4, Kim, Jin5, Seo, Mirinae3, Moon, Woo3 moonwk@snu.ac.kr
Source: European Radiology. Mar2014, Vol. 24 Issue 3, p610-618. 9p. 3 Color Photographs, 1 Chart, 3 Graphs.
Subjects: Positron emission tomography, Breast cancer research, Immunohistochemistry, HER2 protein, Lymph nodes, Regression analysis
Abstract: Objectives: To determine whether a correlation exists between maximum standardized uptake value (SUV) on F-fluorodeoxyglucose positron emission tomography (FDG-PET) and the subtypes of breast cancer. Methods: This retrospective study involved 548 patients (mean age 51.6 years, range 21-81 years) with 552 index breast cancers (mean size 2.57 cm, range 1.0-14.5 cm). The correlation between F-FDG uptake in PET/CT, expressed as SUV, and immunohistochemically defined subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) positive and triple negative) was analyzed. Results: The mean SUV value of the 552 tumours was 6.07 ± 4.63 (range 0.9-32.8). The subtypes of the 552 tumours were 334 (60 %) luminal A, 66 (12 %) luminal B, 60 (11 %) HER2 positive and 92 (17 %) triple negative, for which the mean SUV values were 4.69 ± 3.45, 6.51 ± 4.18, 7.44 ± 4.73 and 9.83 ± 6.03, respectively. In a multivariate regression analysis, triple-negative and HER2-positive tumours had 1.67-fold ( P < 0.001) and 1.27-fold ( P = 0.009) higher SUV values, respectively, than luminal A tumours after adjustment for invasive tumour size, lymph node involvement status and histologic grade. Conclusion: FDG uptake was independently associated with subtypes of invasive breast cancer. Triple-negative and HER2-positive breast cancers showed higher SUV values than luminal A tumours. Key Points: • F-FDG PET demonstrates increased tissue glucose metabolism, a hallmark of cancers. • Immunohistochemically defined subtypes appear significantly associated with FDG uptake (expressed as SUV ). • Triple-negative tumours had 1.67-fold higher SUV values than luminal A tumours. • HER2-positive tumours had 1.27-fold higher SUV values than luminal A tumours. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:Objectives: To determine whether a correlation exists between maximum standardized uptake value (SUV) on F-fluorodeoxyglucose positron emission tomography (FDG-PET) and the subtypes of breast cancer. Methods: This retrospective study involved 548 patients (mean age 51.6 years, range 21-81 years) with 552 index breast cancers (mean size 2.57 cm, range 1.0-14.5 cm). The correlation between F-FDG uptake in PET/CT, expressed as SUV, and immunohistochemically defined subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) positive and triple negative) was analyzed. Results: The mean SUV value of the 552 tumours was 6.07 ± 4.63 (range 0.9-32.8). The subtypes of the 552 tumours were 334 (60 %) luminal A, 66 (12 %) luminal B, 60 (11 %) HER2 positive and 92 (17 %) triple negative, for which the mean SUV values were 4.69 ± 3.45, 6.51 ± 4.18, 7.44 ± 4.73 and 9.83 ± 6.03, respectively. In a multivariate regression analysis, triple-negative and HER2-positive tumours had 1.67-fold ( P < 0.001) and 1.27-fold ( P = 0.009) higher SUV values, respectively, than luminal A tumours after adjustment for invasive tumour size, lymph node involvement status and histologic grade. Conclusion: FDG uptake was independently associated with subtypes of invasive breast cancer. Triple-negative and HER2-positive breast cancers showed higher SUV values than luminal A tumours. Key Points: • F-FDG PET demonstrates increased tissue glucose metabolism, a hallmark of cancers. • Immunohistochemically defined subtypes appear significantly associated with FDG uptake (expressed as SUV ). • Triple-negative tumours had 1.67-fold higher SUV values than luminal A tumours. • HER2-positive tumours had 1.27-fold higher SUV values than luminal A tumours. [ABSTRACT FROM AUTHOR]
ISSN:09387994
DOI:10.1007/s00330-013-3037-1