Prevalence of Multidrug-Resistant Organisms During Hospitalization and Its Association with Patient's Functional Status at Discharge: A Retrospective Cohort Study.
Saved in:
| Title: | Prevalence of Multidrug-Resistant Organisms During Hospitalization and Its Association with Patient's Functional Status at Discharge: A Retrospective Cohort Study. |
|---|---|
| Authors: | Guglielmi, Sara1 (NURSE), Vedovelli, Luca2 (AUTHOR), Santarossa, Adriano1 (NURSE), Marconato, Sabrina1 (AUTHOR), Longhini, Jessica2 (NURSE), Danielis, Matteo2 (NURSE) matteo.danielis@unipd.it |
| Source: | Inquiry (00469580). 4/21/2026, Vol. 63, p1-11. 11p. |
| Subject Terms: | *Retrospective studies, *Longitudinal method, Patient autonomy, Carbapenems, Enterococcus, Third generation cephalosporins, Statistical models, Cross infection, Bacillus (Bacteria), Gram-positive bacterial infections, Hospital care, Questionnaires, Beta lactam antibiotics, Clostridioides difficile, Immunocompromised patients, Functional assessment, Multiple regression analysis, Multidrug resistance, Functional status, Discharge planning, Disease prevalence, Reverse transcriptase polymerase chain reaction, Vancomycin resistance, Methicillin-resistant staphylococcus aureus, Burkholderia, Descriptive statistics, Vancomycin, Enterobacteriaceae, Enterococcus faecium, Aspergillus, Convalescence, Barthel Index, Length of stay in hospitals, Beta lactamases, Carbapenem-resistant bacteria, Gram-negative bacterial diseases, Data analysis software, Confidence intervals, Pseudomonas, Activities of daily living |
| Geographic Terms: | Italy |
| Abstract: | Multidrug-resistant organisms (MDROs) represent a growing global threat due to resistance to multiple antibiotics, limited treatment options, longer hospitalizations, higher costs, and increased mortality. Although the clinical impact of MDROs is well recognized, their effect on patients' functional recovery remains understudied. This study aimed to determine the prevalence of MDRO infections across hospital settings and examine their association with changes in functional status. A retrospective cohort study analyzed 30 428 adult hospitalizations from 2020 to 2023 in a 294-bed hospital in northern Italy. Demographic data, hospitalization characteristics, MDRO status, and Barthel Index scores at admission and discharge were collected. A multilevel linear regression model examined the effect of MDRO infection on Barthel variation, adjusting for age, sex, discharge area, and length of stay. MDRO infections occurred in 2.4% of hospitalizations (n = 732), mainly in medical and surgical wards, with the highest prevalence in medical and rehabilitation areas. The most common pathogens were ESBL-producing Enterobacteriaceae and vancomycin-resistant enterococci. Patients without MDRO infection showed greater improvement in Barthel scores than those with infection (+3.081; P <.001). Functional improvements were highest in rehabilitation and neurology, whereas medical and surgical wards showed declines. Each additional hospital day was associated with a modest increase in functional independence. Age and sex were not significantly related to functional change. MDRO infections are independently associated with reduced functional recovery, underscoring their clinical and rehabilitative burden and highlighting the need for integrated infection control and early rehabilitation strategies. [ABSTRACT FROM AUTHOR] |
| Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Education Research Complete |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | Multidrug-resistant organisms (MDROs) represent a growing global threat due to resistance to multiple antibiotics, limited treatment options, longer hospitalizations, higher costs, and increased mortality. Although the clinical impact of MDROs is well recognized, their effect on patients' functional recovery remains understudied. This study aimed to determine the prevalence of MDRO infections across hospital settings and examine their association with changes in functional status. A retrospective cohort study analyzed 30 428 adult hospitalizations from 2020 to 2023 in a 294-bed hospital in northern Italy. Demographic data, hospitalization characteristics, MDRO status, and Barthel Index scores at admission and discharge were collected. A multilevel linear regression model examined the effect of MDRO infection on Barthel variation, adjusting for age, sex, discharge area, and length of stay. MDRO infections occurred in 2.4% of hospitalizations (n = 732), mainly in medical and surgical wards, with the highest prevalence in medical and rehabilitation areas. The most common pathogens were ESBL-producing Enterobacteriaceae and vancomycin-resistant enterococci. Patients without MDRO infection showed greater improvement in Barthel scores than those with infection (+3.081; P <.001). Functional improvements were highest in rehabilitation and neurology, whereas medical and surgical wards showed declines. Each additional hospital day was associated with a modest increase in functional independence. Age and sex were not significantly related to functional change. MDRO infections are independently associated with reduced functional recovery, underscoring their clinical and rehabilitative burden and highlighting the need for integrated infection control and early rehabilitation strategies. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 00469580 |
| DOI: | 10.1177/00469580261438321 |
