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Prevalence of Multidrug-Resistant Organisms During Hospitalization and Its Association with Patient's Functional Status at Discharge: A Retrospective Cohort Study.

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Title: Prevalence of Multidrug-Resistant Organisms During Hospitalization and Its Association with Patient's Functional Status at Discharge: A Retrospective Cohort Study.
Authors: Guglielmi, Sara1 (NURSE), Vedovelli, Luca2 (AUTHOR), Santarossa, Adriano1 (NURSE), Marconato, Sabrina1 (AUTHOR), Longhini, Jessica2 (NURSE), Danielis, Matteo2 (NURSE) matteo.danielis@unipd.it
Source: Inquiry (00469580). 4/21/2026, Vol. 63, p1-11. 11p.
Subject Terms: *Retrospective studies, *Longitudinal method, Patient autonomy, Carbapenems, Enterococcus, Third generation cephalosporins, Statistical models, Cross infection, Bacillus (Bacteria), Gram-positive bacterial infections, Hospital care, Questionnaires, Beta lactam antibiotics, Clostridioides difficile, Immunocompromised patients, Functional assessment, Multiple regression analysis, Multidrug resistance, Functional status, Discharge planning, Disease prevalence, Reverse transcriptase polymerase chain reaction, Vancomycin resistance, Methicillin-resistant staphylococcus aureus, Burkholderia, Descriptive statistics, Vancomycin, Enterobacteriaceae, Enterococcus faecium, Aspergillus, Convalescence, Barthel Index, Length of stay in hospitals, Beta lactamases, Carbapenem-resistant bacteria, Gram-negative bacterial diseases, Data analysis software, Confidence intervals, Pseudomonas, Activities of daily living
Geographic Terms: Italy
Abstract: Multidrug-resistant organisms (MDROs) represent a growing global threat due to resistance to multiple antibiotics, limited treatment options, longer hospitalizations, higher costs, and increased mortality. Although the clinical impact of MDROs is well recognized, their effect on patients' functional recovery remains understudied. This study aimed to determine the prevalence of MDRO infections across hospital settings and examine their association with changes in functional status. A retrospective cohort study analyzed 30 428 adult hospitalizations from 2020 to 2023 in a 294-bed hospital in northern Italy. Demographic data, hospitalization characteristics, MDRO status, and Barthel Index scores at admission and discharge were collected. A multilevel linear regression model examined the effect of MDRO infection on Barthel variation, adjusting for age, sex, discharge area, and length of stay. MDRO infections occurred in 2.4% of hospitalizations (n = 732), mainly in medical and surgical wards, with the highest prevalence in medical and rehabilitation areas. The most common pathogens were ESBL-producing Enterobacteriaceae and vancomycin-resistant enterococci. Patients without MDRO infection showed greater improvement in Barthel scores than those with infection (+3.081; P <.001). Functional improvements were highest in rehabilitation and neurology, whereas medical and surgical wards showed declines. Each additional hospital day was associated with a modest increase in functional independence. Age and sex were not significantly related to functional change. MDRO infections are independently associated with reduced functional recovery, underscoring their clinical and rehabilitative burden and highlighting the need for integrated infection control and early rehabilitation strategies. [ABSTRACT FROM AUTHOR]
Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Prevalence of Multidrug-Resistant Organisms During Hospitalization and Its Association with Patient&#39;s Functional Status at Discharge: A Retrospective Cohort Study.
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  Data: Multidrug-resistant organisms (MDROs) represent a growing global threat due to resistance to multiple antibiotics, limited treatment options, longer hospitalizations, higher costs, and increased mortality. Although the clinical impact of MDROs is well recognized, their effect on patients&#39; functional recovery remains understudied. This study aimed to determine the prevalence of MDRO infections across hospital settings and examine their association with changes in functional status. A retrospective cohort study analyzed 30 428 adult hospitalizations from 2020 to 2023 in a 294-bed hospital in northern Italy. Demographic data, hospitalization characteristics, MDRO status, and Barthel Index scores at admission and discharge were collected. A multilevel linear regression model examined the effect of MDRO infection on Barthel variation, adjusting for age, sex, discharge area, and length of stay. MDRO infections occurred in 2.4% of hospitalizations (n = 732), mainly in medical and surgical wards, with the highest prevalence in medical and rehabilitation areas. The most common pathogens were ESBL-producing Enterobacteriaceae and vancomycin-resistant enterococci. Patients without MDRO infection showed greater improvement in Barthel scores than those with infection (+3.081; P &lt;.001). Functional improvements were highest in rehabilitation and neurology, whereas medical and surgical wards showed declines. Each additional hospital day was associated with a modest increase in functional independence. Age and sex were not significantly related to functional change. MDRO infections are independently associated with reduced functional recovery, underscoring their clinical and rehabilitative burden and highlighting the need for integrated infection control and early rehabilitation strategies. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=193226626
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    Identifiers:
      – Type: doi
        Value: 10.1177/00469580261438321
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
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        PageCount: 11
        StartPage: 1
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      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Patient autonomy
        Type: general
      – SubjectFull: Carbapenems
        Type: general
      – SubjectFull: Enterococcus
        Type: general
      – SubjectFull: Third generation cephalosporins
        Type: general
      – SubjectFull: Statistical models
        Type: general
      – SubjectFull: Cross infection
        Type: general
      – SubjectFull: Bacillus (Bacteria)
        Type: general
      – SubjectFull: Gram-positive bacterial infections
        Type: general
      – SubjectFull: Hospital care
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Beta lactam antibiotics
        Type: general
      – SubjectFull: Clostridioides difficile
        Type: general
      – SubjectFull: Immunocompromised patients
        Type: general
      – SubjectFull: Functional assessment
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Multidrug resistance
        Type: general
      – SubjectFull: Functional status
        Type: general
      – SubjectFull: Discharge planning
        Type: general
      – SubjectFull: Disease prevalence
        Type: general
      – SubjectFull: Reverse transcriptase polymerase chain reaction
        Type: general
      – SubjectFull: Vancomycin resistance
        Type: general
      – SubjectFull: Methicillin-resistant staphylococcus aureus
        Type: general
      – SubjectFull: Burkholderia
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Vancomycin
        Type: general
      – SubjectFull: Enterobacteriaceae
        Type: general
      – SubjectFull: Enterococcus faecium
        Type: general
      – SubjectFull: Aspergillus
        Type: general
      – SubjectFull: Convalescence
        Type: general
      – SubjectFull: Barthel Index
        Type: general
      – SubjectFull: Length of stay in hospitals
        Type: general
      – SubjectFull: Beta lactamases
        Type: general
      – SubjectFull: Carbapenem-resistant bacteria
        Type: general
      – SubjectFull: Gram-negative bacterial diseases
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      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Pseudomonas
        Type: general
      – SubjectFull: Activities of daily living
        Type: general
      – SubjectFull: Italy
        Type: general
    Titles:
      – TitleFull: Prevalence of Multidrug-Resistant Organisms During Hospitalization and Its Association with Patient's Functional Status at Discharge: A Retrospective Cohort Study.
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              Text: 4/21/2026
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