Bibliographic Details
| Title: |
Model for Muscle Regeneration around Fibrotic Lesions in Recurrent Strain Injuries. |
| Authors: |
Grefte, Sander1, Kuijpers-Jagtman, Anne Marie1, Torensma, Ruurd2, Von Den Hoff, Johannes W.1 H.vondenHoff@dent.umcn.nl |
| Source: |
Medicine & Science in Sports & Exercise. Apr2010, Vol. 42 Issue 4, p813-819. 7p. |
| Subject Terms: |
Muscle regeneration, Physiologic strain, Suturing, Ligature (Surgery), Collagen, Satellite cells, Wound care, Biological models, Laboratory rats |
| Abstract: |
The article presents a study which aims to establish a model for the regeneration of muscle around fibrotic lesions after strain injuries. It states that 24 five-week-old male rats were housed in a laboratory under normal conditions and underwent experimental procedures. The rats' musculus soleus was exposed, lacerated, and sutured together in between muscle ends, with or without collagen scaffold. Out of the 24 rats, only one with no collagen scaffold was not able to survive the surgery. The results show that the satellite cells around the wounds were activated; however, these cells were not present in the wounds with collagen scaffold, which indicates that the regeneration of the muscle was impaired. It concludes that the model is suitable to evaluate new strain injury treatments. |
| Database: |
Education Research Complete |
