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Finger Tapping-Related Activation Differences in Treatment-Naive Pediatric Tourette Syndrome: A Comparison of the Preferred and Nonpreferred Hand

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Bibliographic Details
Title: Finger Tapping-Related Activation Differences in Treatment-Naive Pediatric Tourette Syndrome: A Comparison of the Preferred and Nonpreferred Hand
Language: English
Authors: Roessner, Veit, Wittfoth, Matthias, August, Julia M., Rothenberger, Aribert, Baudewig, Jurgen, Dechent, Peter
Source: Journal of Child Psychology and Psychiatry. Mar 2013 54(3):273-279.
Availability: Wiley-Blackwell. 350 Main Street, Malden, MA 02148. Tel: 800-835-6770; Tel: 781-388-8598; Fax: 781-388-8232; e-mail: cs-journals@wiley.com; Web site: http://www.wiley.com/WileyCDA/
Peer Reviewed: Y
Page Count: 7
Publication Date: 2013
Document Type: Journal Articles
Reports - Research
Descriptors: Neurological Impairments, Foreign Countries, Males, Early Adolescents, Preadolescents, Brain Hemisphere Functions, Diagnostic Tests, Human Body, Motion, Attention Deficit Hyperactivity Disorder, Symptoms (Individual Disorders), Handedness, Severity (of Disability), Comparative Analysis, Correlation, Behavior Disorders, Hypothesis Testing, Observation, Semi Structured Interviews
Geographic Terms: Germany
Assessment and Survey Identifiers: Edinburgh Handedness Inventory, Strengths and Difficulties Questionnaire, Wechsler Intelligence Scale for Children
DOI: 10.1111/j.1469-7610.2012.02584.x
ISSN: 0021-9630
Abstract: Background: Disturbances of motor circuitry are commonly encountered in Tourette syndrome (TS). The aim of this study was to investigate simple motor performance differences between boys with TS and healthy controls. Methods: We attempted to provide insight into motor network alterations by studying a group of treatment-naive patients suffering from "pure" TS, i.e., without comorbid symptomatology at an early stage of disease. We used functional MRI to compare activation patterns during right (preferred) and left (nonpreferred) index finger tapping between 22 TS boys (12.6 plus/minus 1.7 years) and 22 age-matched healthy control boys. Results: Boys with TS revealed altered motor network recruitment for right (dominant) and left (nondominant) index finger tapping. Brain activation patterns in response to index finger tapping of the nonpreferred left hand reflected the most prominent differences, including activation decrease in contralateral sensorimotor cortex while recruiting premotor and prefrontal regions along with the left inferior parietal lobule to a greater extent. Conclusions: This study demonstrates clear functional differences of simple index finger tapping in early-stage TS. We suggest that this reflects the requirement for additional brain networks to keep a normal performance level during the actual task and adaptive mechanisms due to continuous tic suppression and performance in TS. (Contains 2 tables and 1 figure.)
Abstractor: As Provided
Number of References: 38
Entry Date: 2014
Accession Number: EJ1012810
Database: ERIC
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Abstract:Background: Disturbances of motor circuitry are commonly encountered in Tourette syndrome (TS). The aim of this study was to investigate simple motor performance differences between boys with TS and healthy controls. Methods: We attempted to provide insight into motor network alterations by studying a group of treatment-naive patients suffering from "pure" TS, i.e., without comorbid symptomatology at an early stage of disease. We used functional MRI to compare activation patterns during right (preferred) and left (nonpreferred) index finger tapping between 22 TS boys (12.6 plus/minus 1.7 years) and 22 age-matched healthy control boys. Results: Boys with TS revealed altered motor network recruitment for right (dominant) and left (nondominant) index finger tapping. Brain activation patterns in response to index finger tapping of the nonpreferred left hand reflected the most prominent differences, including activation decrease in contralateral sensorimotor cortex while recruiting premotor and prefrontal regions along with the left inferior parietal lobule to a greater extent. Conclusions: This study demonstrates clear functional differences of simple index finger tapping in early-stage TS. We suggest that this reflects the requirement for additional brain networks to keep a normal performance level during the actual task and adaptive mechanisms due to continuous tic suppression and performance in TS. (Contains 2 tables and 1 figure.)
ISSN:0021-9630
DOI:10.1111/j.1469-7610.2012.02584.x