Working Memory and Response Inhibition as One Integral Phenotype of Adult ADHD? A Behavioral and Imaging Correlational Investigation
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| Title: | Working Memory and Response Inhibition as One Integral Phenotype of Adult ADHD? A Behavioral and Imaging Correlational Investigation |
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| Language: | English |
| Authors: | Schecklmann, Martin, Ehlis, Ann-Christine, Plichta, Michael M., Dresler, Thomas, Heine, Monika, Boreatti-Hummer, Andrea, Romanos, Marcel, Jacob, Christian, Pauli, Paul, Fallgatter, Andreas J. |
| Source: | Journal of Attention Disorders. Aug 2013 17(6):470-482. |
| Availability: | SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: http://sagepub.com |
| Peer Reviewed: | Y |
| Page Count: | 13 |
| Publication Date: | 2013 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Attention Deficit Hyperactivity Disorder, Genetics, Task Analysis, Patients, Control Groups, Adults, Correlation, Short Term Memory, Age Differences, Gender Differences, Intelligence, Educational Attainment, Reaction Time, Brain Hemisphere Functions, Spectroscopy, Conceptual Tempo, Interviews, Foreign Countries |
| Geographic Terms: | Germany |
| DOI: | 10.1177/1087054711429702 |
| ISSN: | 1087-0547 |
| Abstract: | Objective: It is an open question whether working memory (WM) and response inhibition (RI) constitute one integral phenotype in attention deficit hyperactivity disorder (ADHD). Method: The authors investigated 45 adult ADHD patients and 41 controls comparable for age, gender, intelligence, and education during a letter n-back and a stop-signal task, and measured prefrontal oxygenation by means of functional near-infrared spectroscopy. Results: The authors replicated behavioral and cortical activation deficits in patients compared with controls for both tasks and also for performance in both control conditions. In the patient group, 2-back performance was correlated with stop-signal reaction time. This correlation did not seem to be specific for WM and RI as 1-back performance was correlated with go reaction time. No significant correlations of prefrontal oxygenation between WM and RI were found. Conclusion: The authors' findings do not support the hypothesis of WM and RI representing one integral phenotype of ADHD mediated by the prefrontal cortex. (Contains 2 tables and 2 figures.) |
| Abstractor: | As Provided |
| Number of References: | 70 |
| Entry Date: | 2014 |
| Accession Number: | EJ1015303 |
| Database: | ERIC |
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| Abstract: | Objective: It is an open question whether working memory (WM) and response inhibition (RI) constitute one integral phenotype in attention deficit hyperactivity disorder (ADHD). Method: The authors investigated 45 adult ADHD patients and 41 controls comparable for age, gender, intelligence, and education during a letter n-back and a stop-signal task, and measured prefrontal oxygenation by means of functional near-infrared spectroscopy. Results: The authors replicated behavioral and cortical activation deficits in patients compared with controls for both tasks and also for performance in both control conditions. In the patient group, 2-back performance was correlated with stop-signal reaction time. This correlation did not seem to be specific for WM and RI as 1-back performance was correlated with go reaction time. No significant correlations of prefrontal oxygenation between WM and RI were found. Conclusion: The authors' findings do not support the hypothesis of WM and RI representing one integral phenotype of ADHD mediated by the prefrontal cortex. (Contains 2 tables and 2 figures.) |
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| ISSN: | 1087-0547 |
| DOI: | 10.1177/1087054711429702 |
