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Parent Stress in a Randomized Clinical Trial of Atomoxetine and Parent Training for Children with Autism Spectrum Disorder

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Bibliographic Details
Title: Parent Stress in a Randomized Clinical Trial of Atomoxetine and Parent Training for Children with Autism Spectrum Disorder
Language: English
Authors: Lecavalier, Luc (ORCID 0000-0002-1162-659X), Pan, Xueliang, Smith, Tristram, Handen, Benjamin L., Arnold, L. Eugene, Silverman, Laura, Tumuluru, Rameshwari V., Hollway, Jill, Aman, Michael G.
Source: Journal of Autism and Developmental Disorders. Apr 2018 48(4):980-987.
Availability: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Peer Reviewed: Y
Page Count: 8
Publication Date: 2018
Sponsoring Agency: National Institute of Mental Health (DHHS/NIH)
National Center for Research Resources (NIH/DHHS)
National Center for Advancing Translational Sciences (NCATS) (DHHS/NIH)
Contract Number: 5R01MH079080
5R01MH07908205
5R01MH083247
UL1RR024160
UL1TR001070
Document Type: Journal Articles
Reports - Research
Education Level: Adult Education
Descriptors: Parents, Anxiety, Stress Variables, Pervasive Developmental Disorders, Autism, Randomized Controlled Trials, Drug Therapy, Attention Deficit Hyperactivity Disorder, Children, Early Adolescents, Student Behavior, Experimental Groups, Symptoms (Individual Disorders), Parent Education
DOI: 10.1007/s10803-017-3345-4
ISSN: 0162-3257
Abstract: We previously reported a 2 × 2 randomized clinical trial of atomoxetine (ATX) and parent training (PT) for attention deficit hyperactivity disorder (ADHD) symptoms and behavioral noncompliance in 128 children with autism spectrum disorder, ages 5-14 years. Children were randomized to one of four conditions: ATX alone, placebo alone, ATX + PT, or PT + placebo. Both ATX and PT improved some indices of ADHD and behavioral compliance. In this report, we describe parent stress over time and across conditions. All four treatments improved parent self-rated stress from baseline to week 10. However, there were no statistically significant differences between treatment groups. Significantly more improvement in parent stress scores was observed for clinical responders than non-responders. ClinicalTrials.gov Title: Atomoxetine, Placebo and Parent Management Training in Autism (Strattera) ClinicalTrials.gov Identifier: NCT00844753.
Abstractor: As Provided
Number of References: 31
Entry Date: 2018
Accession Number: EJ1173389
Database: ERIC
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Abstract:We previously reported a 2 × 2 randomized clinical trial of atomoxetine (ATX) and parent training (PT) for attention deficit hyperactivity disorder (ADHD) symptoms and behavioral noncompliance in 128 children with autism spectrum disorder, ages 5-14 years. Children were randomized to one of four conditions: ATX alone, placebo alone, ATX + PT, or PT + placebo. Both ATX and PT improved some indices of ADHD and behavioral compliance. In this report, we describe parent stress over time and across conditions. All four treatments improved parent self-rated stress from baseline to week 10. However, there were no statistically significant differences between treatment groups. Significantly more improvement in parent stress scores was observed for clinical responders than non-responders. ClinicalTrials.gov Title: Atomoxetine, Placebo and Parent Management Training in Autism (Strattera) ClinicalTrials.gov Identifier: NCT00844753.
ISSN:0162-3257
DOI:10.1007/s10803-017-3345-4