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Autism Spectrum Disorder in an Unselected Cohort of Children with Neurofibromatosis Type 1 (NF1)

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Bibliographic Details
Title: Autism Spectrum Disorder in an Unselected Cohort of Children with Neurofibromatosis Type 1 (NF1)
Language: English
Authors: Eijk, S., Mous, S. E., Dieleman, G. C., Dierckx, B., Rietman, A. B., de Nijs, P. F. A., ten Hoopen, L. W., van Minkelen, R., Elgersma, Y., Catsman-Berrevoets, C. E., Oostenbrink, R., Legerstee, J. S.
Source: Journal of Autism and Developmental Disorders. Jul 2018 48(7):2278-2285.
Availability: Springer. Available from: Springer Nature. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
Peer Reviewed: Y
Page Count: 8
Publication Date: 2018
Document Type: Journal Articles
Reports - Research
Descriptors: Autism, Pervasive Developmental Disorders, Children, Neurological Impairments, Incidence, Diagnostic Tests, Observation, Prediction, Foreign Countries, Cognitive Development, Intelligence Tests, Young Children, Statistical Analysis
Geographic Terms: Netherlands
Assessment and Survey Identifiers: Autism Diagnostic Observation Schedule, Wechsler Preschool and Primary Scale of Intelligence
DOI: 10.1007/s10803-018-3478-0
ISSN: 0162-3257
Abstract: In a non-selected sample of children with Neurofibromatosis type 1 (NF1) the prevalence rate of autism spectrum disorder (ASD) and predictive value of an observational (ADOS)--and questionnaire-based screening instrument were assessed. Complete data was available for 128 children. The prevalence rate for clinical ASD was 10.9%, which is clearly higher than in the general population. This prevalence rate is presumably more accurate than in previous studies that examined children with NF1 with an ASD presumption or solely based on screening instruments. The combined observational- and screening based classifications demonstrated the highest positive predictive value for DSM-IV diagnosis, highlighting the importance of using both instruments in children with NF1.
Abstractor: As Provided
Number of References: 36
Entry Date: 2018
Accession Number: EJ1182065
Database: ERIC
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Abstract:In a non-selected sample of children with Neurofibromatosis type 1 (NF1) the prevalence rate of autism spectrum disorder (ASD) and predictive value of an observational (ADOS)--and questionnaire-based screening instrument were assessed. Complete data was available for 128 children. The prevalence rate for clinical ASD was 10.9%, which is clearly higher than in the general population. This prevalence rate is presumably more accurate than in previous studies that examined children with NF1 with an ASD presumption or solely based on screening instruments. The combined observational- and screening based classifications demonstrated the highest positive predictive value for DSM-IV diagnosis, highlighting the importance of using both instruments in children with NF1.
ISSN:0162-3257
DOI:10.1007/s10803-018-3478-0