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EEG Spectral Features in Sleep of Autism Spectrum Disorders in Children with Tuberous Sclerosis Complex

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Bibliographic Details
Title: EEG Spectral Features in Sleep of Autism Spectrum Disorders in Children with Tuberous Sclerosis Complex
Language: English
Authors: Cook, Ian A. (ORCID 0000-0002-8991-3804), Wilson, Andrew C., Peters, Jurriaan M. (ORCID 0000-0002-6725-2814), Goyal, Monisha N., Bebin, E. Martina (ORCID 0000-0002-0304-4266), Northrup, Hope (ORCID 0000-0002-2892-0840), Krueger, Darcy (ORCID 0000-0002-7250-7391), Leuchter, Andrew F. (ORCID 0000-0003-2402-7083), Sahin, Mustafa (ORCID 0000-0001-7044-2953)
Source: Journal of Autism and Developmental Disorders. Mar 2020 50(3):916-923.
Availability: Springer. Available from: Springer Nature. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
Peer Reviewed: Y
Page Count: 8
Publication Date: 2020
Sponsoring Agency: National Institute of Neurological Disorders and Stroke (NIH)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (NIH)
Contract Number: U01NS082320
Document Type: Journal Articles
Reports - Research
Descriptors: Diagnostic Tests, Sleep, Autism, Pervasive Developmental Disorders, Children, Symptoms (Individual Disorders), Genetic Disorders, Brain, Neurological Impairments
DOI: 10.1007/s10803-019-04326-0
ISSN: 0162-3257
Abstract: Tuberous sclerosis complex (TSC) is a multisystem disorder with increased prevalence of autism spectrum disorders (ASDs). This project aimed to characterize the autism phenotype of TSC and identify biomarkers of risk for ASD. Because abnormalities of EEG during sleep are tied to neurodevelopment in children, we compared electroencephalographic (EEG) measures during Stage II sleep in TSC children who either did (ASD+) or did not (ASD-) exhibit symptoms of ASD over 36-month follow up. Relative alpha band power was significantly elevated in the ASD+ group at 24 months of age with smaller differences at younger ages, suggesting this may arise from differences in brain development. These findings suggest that EEG features could enhance the detection of risk for ASD.
Abstractor: As Provided
Entry Date: 2020
Accession Number: EJ1243057
Database: ERIC
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Abstract:Tuberous sclerosis complex (TSC) is a multisystem disorder with increased prevalence of autism spectrum disorders (ASDs). This project aimed to characterize the autism phenotype of TSC and identify biomarkers of risk for ASD. Because abnormalities of EEG during sleep are tied to neurodevelopment in children, we compared electroencephalographic (EEG) measures during Stage II sleep in TSC children who either did (ASD+) or did not (ASD-) exhibit symptoms of ASD over 36-month follow up. Relative alpha band power was significantly elevated in the ASD+ group at 24 months of age with smaller differences at younger ages, suggesting this may arise from differences in brain development. These findings suggest that EEG features could enhance the detection of risk for ASD.
ISSN:0162-3257
DOI:10.1007/s10803-019-04326-0