The Search for Biomarkers of Alzheimer's Disease in Down Syndrome
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| Title: | The Search for Biomarkers of Alzheimer's Disease in Down Syndrome |
|---|---|
| Language: | English |
| Authors: | Handen, Benjamin L. |
| Source: | American Journal on Intellectual and Developmental Disabilities. Mar 2020 125(2):97-99. |
| Availability: | American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://www.aaiddjournals.org/ |
| Peer Reviewed: | Y |
| Page Count: | 3 |
| Publication Date: | 2020 |
| Sponsoring Agency: | National Institute on Aging (DHHS/NIH) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (NIH) |
| Contract Number: | U01AG051412 U01AG051406 |
| Document Type: | Journal Articles Reports - Descriptive |
| Descriptors: | Adults, Down Syndrome, Alzheimers Disease, At Risk Persons, Dementia, Genetic Disorders, Brain, Neurological Impairments |
| DOI: | 10.1352/1944-7558-125.2.97 |
| ISSN: | 1944-7515 |
| Abstract: | Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid [beta] peptides. This article offers a brief overview of our current knowledge of AD in the DS population. In addition, information on an NIA/NICHD-funded, multicenter longitudinal study of biomarkers of AD in adults with DS is provided. |
| Abstractor: | As Provided |
| Entry Date: | 2020 |
| Accession Number: | EJ1244712 |
| Database: | ERIC |
| Abstract: | Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid [beta] peptides. This article offers a brief overview of our current knowledge of AD in the DS population. In addition, information on an NIA/NICHD-funded, multicenter longitudinal study of biomarkers of AD in adults with DS is provided. |
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| ISSN: | 1944-7515 |
| DOI: | 10.1352/1944-7558-125.2.97 |
