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The Search for Biomarkers of Alzheimer's Disease in Down Syndrome

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Title: The Search for Biomarkers of Alzheimer's Disease in Down Syndrome
Language: English
Authors: Handen, Benjamin L.
Source: American Journal on Intellectual and Developmental Disabilities. Mar 2020 125(2):97-99.
Availability: American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://www.aaiddjournals.org/
Peer Reviewed: Y
Page Count: 3
Publication Date: 2020
Sponsoring Agency: National Institute on Aging (DHHS/NIH)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (NIH)
Contract Number: U01AG051412
U01AG051406
Document Type: Journal Articles
Reports - Descriptive
Descriptors: Adults, Down Syndrome, Alzheimers Disease, At Risk Persons, Dementia, Genetic Disorders, Brain, Neurological Impairments
DOI: 10.1352/1944-7558-125.2.97
ISSN: 1944-7515
Abstract: Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid [beta] peptides. This article offers a brief overview of our current knowledge of AD in the DS population. In addition, information on an NIA/NICHD-funded, multicenter longitudinal study of biomarkers of AD in adults with DS is provided.
Abstractor: As Provided
Entry Date: 2020
Accession Number: EJ1244712
Database: ERIC
FullText Links:
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  Data: The Search for Biomarkers of Alzheimer's Disease in Down Syndrome
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  Data: <searchLink fieldCode="SO" term="%22American+Journal+on+Intellectual+and+Developmental+Disabilities%22"><i>American Journal on Intellectual and Developmental Disabilities</i></searchLink>. Mar 2020 125(2):97-99.
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  Data: American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://www.aaiddjournals.org/
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  Data: Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid [beta] peptides. This article offers a brief overview of our current knowledge of AD in the DS population. In addition, information on an NIA/NICHD-funded, multicenter longitudinal study of biomarkers of AD in adults with DS is provided.
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      – SubjectFull: Neurological Impairments
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