Solvent-Free 'N'-Formylation: An Experimental Application of Basic Concepts and Techniques of Organic Chemistry
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| Title: | Solvent-Free 'N'-Formylation: An Experimental Application of Basic Concepts and Techniques of Organic Chemistry |
|---|---|
| Language: | English |
| Authors: | Omar, Yasser M. (ORCID |
| Source: | Journal of Chemical Education. Apr 2020 97(4):1134-1138. |
| Availability: | Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Peer Reviewed: | Y |
| Page Count: | 5 |
| Publication Date: | 2020 |
| Intended Audience: | Teachers |
| Document Type: | Journal Articles Reports - Descriptive |
| Education Level: | Higher Education Postsecondary Education |
| Descriptors: | Science Instruction, Science Experiments, Organic Chemistry, Science Laboratories, Laboratory Safety, Science Process Skills, Laboratory Experiments, College Science, Undergraduate Study |
| DOI: | 10.1021/acs.jchemed.9b00983 |
| ISSN: | 0021-9584 |
| Abstract: | "N"-Formamides are important intermediates in the synthesis of many pharmacologically active compounds and are used as protecting groups for amines or as catalysts in different reactions. The current "N"-formylation experiment is designed as a part of an introductory organic chemistry course for undergraduate students. The experiment includes formylation of substituted aromatic amines using formic acid under solvent-free conditions. Students are introduced to laboratory safety precautions, reaction mechanism, and basic laboratory techniques such as a solvent-free reaction setup, reflux, filtration, melting point determination, yield calculation, and lab report write-up. Students synthesized four different formamides in 50-80% yield as a straightforward application of nucleophilic substitution reactions. |
| Abstractor: | As Provided |
| Entry Date: | 2020 |
| Accession Number: | EJ1250836 |
| Database: | ERIC |
| Abstract: | "N"-Formamides are important intermediates in the synthesis of many pharmacologically active compounds and are used as protecting groups for amines or as catalysts in different reactions. The current "N"-formylation experiment is designed as a part of an introductory organic chemistry course for undergraduate students. The experiment includes formylation of substituted aromatic amines using formic acid under solvent-free conditions. Students are introduced to laboratory safety precautions, reaction mechanism, and basic laboratory techniques such as a solvent-free reaction setup, reflux, filtration, melting point determination, yield calculation, and lab report write-up. Students synthesized four different formamides in 50-80% yield as a straightforward application of nucleophilic substitution reactions. |
|---|---|
| ISSN: | 0021-9584 |
| DOI: | 10.1021/acs.jchemed.9b00983 |
