Process Safety in the Pharmaceutical Industry: A Selection of Illustrative Case Studies
Saved in:
| Title: | Process Safety in the Pharmaceutical Industry: A Selection of Illustrative Case Studies |
|---|---|
| Language: | English |
| Authors: | Dunn, Anna L. (ORCID |
| Source: | Journal of Chemical Education. Jan 2021 98(1):175-182. |
| Availability: | Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Peer Reviewed: | Y |
| Page Count: | 8 |
| Publication Date: | 2021 |
| Document Type: | Journal Articles Reports - Descriptive |
| Education Level: | Higher Education Postsecondary Education |
| Descriptors: | Chemistry, Science Instruction, Teaching Methods, Chemical Engineering, Engineering Education, Safety, Pharmacy, Industry, Case Studies, Hazardous Materials, Heat, Graduate Students, Undergraduate Students |
| DOI: | 10.1021/acs.jchemed.0c00115 |
| ISSN: | 0021-9584 |
| Abstract: | Awareness of best safety practices in the industrial sector will allow students in chemistry and chemical engineering programs to apply these approaches to their own safety assessments. Process safety is a critical function within the pharmaceutical industry to ensure safety when performing reactions. An introduction to process safety and a series of case studies illustrating how safety is routinely considered within the pharmaceutical industry is presented. The concepts presented herein are applicable to multiple industries, academic research, and chemical reactions conducted on all scales. The case studies include examples where a synthesis was redesigned to afford a triazole intermediate without forming potentially explosive byproducts, an exothermic reaction was controlled by understanding the heat output with time and developing a portion-wise addition procedure, and a reaction that displayed extremely fast gas evolution was managed by using an alternative solvent and controlling the rate of reagent addition. |
| Abstractor: | As Provided |
| Entry Date: | 2021 |
| Accession Number: | EJ1283515 |
| Database: | ERIC |
| Abstract: | Awareness of best safety practices in the industrial sector will allow students in chemistry and chemical engineering programs to apply these approaches to their own safety assessments. Process safety is a critical function within the pharmaceutical industry to ensure safety when performing reactions. An introduction to process safety and a series of case studies illustrating how safety is routinely considered within the pharmaceutical industry is presented. The concepts presented herein are applicable to multiple industries, academic research, and chemical reactions conducted on all scales. The case studies include examples where a synthesis was redesigned to afford a triazole intermediate without forming potentially explosive byproducts, an exothermic reaction was controlled by understanding the heat output with time and developing a portion-wise addition procedure, and a reaction that displayed extremely fast gas evolution was managed by using an alternative solvent and controlling the rate of reagent addition. |
|---|---|
| ISSN: | 0021-9584 |
| DOI: | 10.1021/acs.jchemed.0c00115 |
