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Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

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Bibliographic Details
Title: Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder
Language: English
Authors: Casey, S. (ORCID 0000-0001-7704-3568), Carter, M., Looney, A. M., Livingstone, V., Moloney, G., O'Keeffe, G. W., Taylor, R. S., Kenny, L. C., McCarthy, F. P., McCowan, L. M. E., Thompson, J. M. D., Murray, D. M.
Source: Journal of Autism and Developmental Disorders. Sep 2022 52(9):3919-3932.
Availability: Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
Peer Reviewed: Y
Page Count: 14
Publication Date: 2022
Document Type: Journal Articles
Reports - Research
Descriptors: Mothers, Children, Autism, Pervasive Developmental Disorders, Metabolism, Pregnancy, Child Development
DOI: 10.1007/s10803-021-05271-7
ISSN: 0162-3257
1573-3432
Abstract: Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. [This article was written on behalf of the SCOPE Consortium.]
Abstractor: As Provided
Entry Date: 2022
Accession Number: EJ1343878
Database: ERIC
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Description
Abstract:Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. [This article was written on behalf of the SCOPE Consortium.]
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-021-05271-7