Oxytocin Exposure in Labor and Its Relationship with Cognitive Impairment and the Genetic Architecture of Autism
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| Title: | Oxytocin Exposure in Labor and Its Relationship with Cognitive Impairment and the Genetic Architecture of Autism |
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| Language: | English |
| Authors: | García-Alcón, Alicia (ORCID |
| Source: | Journal of Autism and Developmental Disorders. Jan 2023 53(1):66-79. |
| Availability: | Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
| Peer Reviewed: | Y |
| Page Count: | 14 |
| Publication Date: | 2023 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Genetics, Autism Spectrum Disorders, Prenatal Influences, Prenatal Care, Birth, Risk, Symptoms (Individual Disorders), Cognitive Development |
| DOI: | 10.1007/s10803-021-05409-7 |
| ISSN: | 0162-3257 1573-3432 |
| Abstract: | Whether there is a relationship between oxytocin (OXT) use in labor and the risk of autism (ASD), and the nature of such relationship, is unclear. By integrating genetic and clinical data in a sample of 176 ASD participants, we tested the hypothesis that OXT is a marker for abnormal prenatal development which leads to impairments in the process of labor. OXT-exposed ASD had more obstetric complications (P = 0.031), earlier onset of symptoms (P = 0.027), poorer cognitive development (P = 0.011), higher mutation burden across neurodevelopment genes (P = 0.020; OR = 5.33) and lower transmission of polygenic risk for ASD (P = 0.0319), than non-exposed ASD. OXT seems to constitute a risk indicator rather than a risk factor for ASD, which is relevant for diagnostic and genetic counselling. |
| Abstractor: | As Provided |
| Entry Date: | 2023 |
| Accession Number: | EJ1364437 |
| Database: | ERIC |
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| Abstract: | Whether there is a relationship between oxytocin (OXT) use in labor and the risk of autism (ASD), and the nature of such relationship, is unclear. By integrating genetic and clinical data in a sample of 176 ASD participants, we tested the hypothesis that OXT is a marker for abnormal prenatal development which leads to impairments in the process of labor. OXT-exposed ASD had more obstetric complications (P = 0.031), earlier onset of symptoms (P = 0.027), poorer cognitive development (P = 0.011), higher mutation burden across neurodevelopment genes (P = 0.020; OR = 5.33) and lower transmission of polygenic risk for ASD (P = 0.0319), than non-exposed ASD. OXT seems to constitute a risk indicator rather than a risk factor for ASD, which is relevant for diagnostic and genetic counselling. |
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| ISSN: | 0162-3257 1573-3432 |
| DOI: | 10.1007/s10803-021-05409-7 |
